CAJ | 학술논문

肝细胞癌(HCC)是指原发于肝细胞的恶性肿瘤,占原发性肝癌的91.5%。目前肝细胞癌的治疗方法很多,其中骨髓干细胞(BMSCs))移植是肝细胞癌治疗的热点之一。 BMSCs可促进肝组织再生,减缓肝硬化进程并诱导HCC凋亡。同时,BMSCs可以通过自分泌和旁分泌的方式改变HCC周围的微环境,从而抑制HCC向肝外组织的转移。随着分子生物技术的不断进步,BMSCs由于易于分离、体内扩增及进行基因修饰,已成为基因治疗的理想靶向细胞。然而,随着研究的深入,BMSCs的致瘤性风险也受到研究者的重视。本研究从BMSCs对肝癌组织及其转移的影响,BMSCs作为理想靶向细胞应用于基因治疗及BMSCs致瘤性的可能风险等方面的研究进展做一综述。
간세포암(HCC)시지원발우간세포적악성종류,점원발성간암적91.5%。목전간세포암적치료방법흔다,기중골수간세포(BMSCs))이식시간세포암치료적열점지일。 BMSCs가촉진간조직재생,감완간경화진정병유도HCC조망。동시,BMSCs가이통과자분비화방분비적방식개변HCC주위적미배경,종이억제HCC향간외조직적전이。수착분자생물기술적불단진보,BMSCs유우역우분리、체내확증급진행기인수식,이성위기인치료적이상파향세포。연이,수착연구적심입,BMSCs적치류성풍험야수도연구자적중시。본연구종BMSCs대간암조직급기전이적영향,BMSCs작위이상파향세포응용우기인치료급BMSCs치류성적가능풍험등방면적연구진전주일종술。
Hepatocellular carcinoma (HCC) refers to the primary liver cell malignant tumor, which is 91.5%of prima-ry liver cancer. Recurrently there are many methods of treating HCC and bone marrow stem cells (BMSCs) transplanta-tion is one of the hot spot on treating HCC. BMSCs can promote liver regeneration, slow down the process of cirrhosis and induce the apoptosis of HCC. At the same time, BMSCs can change the surrounding microenvironment of HCC by autocrine and paracrine, thus inhibiting HCC metastasis. Along with the advance of molecular biotechnology, BMSCs has become the ideal target cells of gene therapy due to the fact that BMSCs are esay to be isolated, expanded in vivo and genetically modified, which has become the ideal target cells of gene therapy. However, with the deepening of re-search, the tumorigenicity risk of BMSCs is also brought to the attention of researchers. This study does a review from BMSCs in liver cancer tissue and its transfer, the influence of BMSCs as the ideal target cells used in gene therapy and possible risk of progression of tumorigenicity by BMSCs.