CAJ | 학술논문

目的：：探讨喹硫平合并石杉碱甲治疗阿尔茨海默病的疗效和安全性。方法：60例在我院住院治疗的阿尔茨海默病患者，符合中国精神障碍分类与诊断标准第3版诊断标准。患者接受为期12周的喹硫平合并石杉碱甲的治疗，在治疗前及治疗2、4、8周采用阳性与阴性症状量表(PANSS)评定疗效，采用治疗中出现的症状量表(TESS)评定不良反应。于治疗前及治疗12周采用简易智力状态量表(MMSE)评定认知功能。结果：治疗8周时 PANSS 评分显著降低，治疗12周 MMSE 评分显著降低，不良反应较少。结论：喹硫平合并石杉碱甲治疗阿尔茨海默病安全有效，不良反应少，耐受性较好。
목적：：탐토규류평합병석삼감갑치료아이자해묵병적료효화안전성。방법：60례재아원주원치료적아이자해묵병환자，부합중국정신장애분류여진단표준제3판진단표준。환자접수위기12주적규류평합병석삼감갑적치료，재치료전급치료2、4、8주채용양성여음성증상량표(PANSS)평정료효，채용치료중출현적증상량표(TESS)평정불량반응。우치료전급치료12주채용간역지력상태량표(MMSE)평정인지공능。결과：치료8주시 PANSS 평분현저강저，치료12주 MMSE 평분현저강저，불량반응교소。결론：규류평합병석삼감갑치료아이자해묵병안전유효，불량반응소，내수성교호。
Objective:To study the efficacy and safety of Quetiapine combined with Huperzine A in treatment of Alzheimer dis-ease. Methods:60 Alzheimer inpatients in our hospital who conform to the Chinese classification and Diagnostic criteria of mental dis-eases-3rd edition undergone the treatment of Quetiapine combined with Huperzine A for 12 weeks. Before and 2, 4 and 8 weeks after the treatment, the efficacy was evaluated by positive and negative symptom scale (PANSS), and the adverse reactions were evaluated by treatment emergent symptom scale (TESS). Before and 12 weeks after the treatment, cognitive functions was evaluated by Mini-mental state examination. Results: The PANSS score reduced significantly 8 weeks after the treatment, The MMSE score reduced sig-nificantly 12 weeks after the treatment and less adverse reactions occurred. Conclusions: Quetiapine combined with Huperzine A in the treatment of Alzheimer disease is a safe and effective treatment with less adverse reactions and more tolerability.