交通医学
交通醫學
교통의학
MEDICAL JOURNAL OF COMMUNICATIONS
2014年
4期
331-333
,共3页
施育华%孙锦卫%王学斌%丁会民
施育華%孫錦衛%王學斌%丁會民
시육화%손금위%왕학빈%정회민
肝细胞肝癌%组织因子%基质金属蛋白酶-2%免疫组织化学法
肝細胞肝癌%組織因子%基質金屬蛋白酶-2%免疫組織化學法
간세포간암%조직인자%기질금속단백매-2%면역조직화학법
hepatocellular carcinoma%tissue factor%matrix metalloproteinase-2%immunohistochemistry
目的:研究肝细胞肝癌组织中的组织因子(TF)及基质金属蛋白酶-2(MMP-2)表达,对肝癌侵袭转移的作用及两者之间的关系。方法:用免疫组织化学EnVisionTM法检测肝癌56例及其癌旁肝组织标本中TF和MMP-2的表达。结果:(1)肝癌组织中TF及MMP-2的阳性表达均明显高于癌旁组织(P<0.05);(2)癌静脉浸润、肝内外转移、无或包膜不完整组织中TF和MMP-2的表达显著高于相应对照组(P<0.05);(3)肝癌中TF表达和MMP-2表达呈正相关。结论:HCC中TF及MMP-2表达明显增高,且与癌侵袭转移有关。
目的:研究肝細胞肝癌組織中的組織因子(TF)及基質金屬蛋白酶-2(MMP-2)錶達,對肝癌侵襲轉移的作用及兩者之間的關繫。方法:用免疫組織化學EnVisionTM法檢測肝癌56例及其癌徬肝組織標本中TF和MMP-2的錶達。結果:(1)肝癌組織中TF及MMP-2的暘性錶達均明顯高于癌徬組織(P<0.05);(2)癌靜脈浸潤、肝內外轉移、無或包膜不完整組織中TF和MMP-2的錶達顯著高于相應對照組(P<0.05);(3)肝癌中TF錶達和MMP-2錶達呈正相關。結論:HCC中TF及MMP-2錶達明顯增高,且與癌侵襲轉移有關。
목적:연구간세포간암조직중적조직인자(TF)급기질금속단백매-2(MMP-2)표체,대간암침습전이적작용급량자지간적관계。방법:용면역조직화학EnVisionTM법검측간암56례급기암방간조직표본중TF화MMP-2적표체。결과:(1)간암조직중TF급MMP-2적양성표체균명현고우암방조직(P<0.05);(2)암정맥침윤、간내외전이、무혹포막불완정조직중TF화MMP-2적표체현저고우상응대조조(P<0.05);(3)간암중TF표체화MMP-2표체정정상관。결론:HCC중TF급MMP-2표체명현증고,차여암침습전이유관。
Objective:To study the expression of tissue factor (TF)and matrix metalloproteinase-2 (MMP-2)in hepa-tocellular carcinoma(HCC) and explore the effects of TF and MMP-2 on cell invasion and metastasis of HCC. Methods:The expression of TF and MMP-2 in 56 specimens of HCC and adjacent normal liver tissues were detected by EnVisionTM immunohistochemistry. Results:The expression levels of TF and MMP-2 were obviously higher in HCC tissues than that in tumor-adjacent normal tissues(P<0.05);MMP-2 and TF expression was correlated to vein invasion, intrahepatic metastasis, and the tumor without envelope (P<0.05).It had coherence abaout the expression of TF and MMP-2 (P<0.01). Conclusion:The expression of TF and MMP-2 HCC may be related to the in invasion and metastasis of HCC.