CAJ | 학술논문

目的：探讨度洛西汀在慢性酒依赖伴抑郁患者中的临床疗效及安全性。方法：将符合条件的66例慢性酒依赖伴抑郁患者随机分成两组，分别给予度洛西汀联合常规戒酒治疗（研究组）和常规戒酒治疗（对照组），进行8周的系统治疗，使用HAMD（汉密尔顿抑郁量表），HAMA（汉密尔顿焦虑量表），CGI（临床疗效总体评估量表），饮酒渴求度评估其疗效；以 TESS （副反应量表）和有关的实验室检查评定药物副反应。结果：治疗以后，研究组与对照组相比较，研究组第1、2、4、8周 HAMD-17、HAMA 、CGI 评分明显下降（P <0.05或 P <0.01）；与对照组相比，研究组第1、2、4、8周的饮酒渴求度明显降低（P <0.05或 P <0.01）。结论：度洛西汀治疗酒依赖伴抑郁安全有效，并能明显降低酒依赖患者的心理渴求。
목적：탐토도락서정재만성주의뢰반억욱환자중적림상료효급안전성。방법：장부합조건적66례만성주의뢰반억욱환자수궤분성량조，분별급여도락서정연합상규계주치료（연구조）화상규계주치료（대조조），진행8주적계통치료，사용HAMD（한밀이돈억욱량표），HAMA（한밀이돈초필량표），CGI（림상료효총체평고량표），음주갈구도평고기료효；이 TESS （부반응량표）화유관적실험실검사평정약물부반응。결과：치료이후，연구조여대조조상비교，연구조제1、2、4、8주 HAMD-17、HAMA 、CGI 평분명현하강（P <0.05혹 P <0.01）；여대조조상비，연구조제1、2、4、8주적음주갈구도명현강저（P <0.05혹 P <0.01）。결론：도락서정치료주의뢰반억욱안전유효，병능명현강저주의뢰환자적심리갈구。
Objective:To explore the efficacy and safety of Duloxetine in treating alcohol abuse patients with depression. Methods:66 alcohol abuse patients with depression were randomly divided into Duloxetine group(n = 33)and Controll group(n = 33). Duloxe-tine group was treated by Duloxetine combined with regular treatment of alcohol abuse. Controll group was treated by regular treatment of alcohol abuse only. They were treated for 8 weeks. The efficacy and safety were evaluated at the baseline and at the end of week 1, 2,4,8 respectively. Results:At the end of the study,The Duloxetine group was significantly improved. The scales of HAMD/ HAMA decreased significantly at the end of week 1,2,4,8 in Duloxetine group(P <0. 05). The Duloxetine group was significantly lowered down the patients alcohol craving. Conclusion:Duloxetine is a safe and effective drug in the treatment of alcohol abuse patients with depression.