CAJ | 학술논문

药物不良反应是指正常剂量的药物用于预防、诊断、治疗疾病或调节生理机能时出现的有害和与用药目的无关的反应。其中药物超敏反应综合征、重症多形红斑、中毒性表皮坏死综合征为常见的重型药物不良反应。本文对目前有关药物不良反应的遗传学研究新进展进行了综述。
약물불량반응시지정상제량적약물용우예방、진단、치료질병혹조절생리궤능시출현적유해화여용약목적무관적반응。기중약물초민반응종합정、중증다형홍반、중독성표피배사종합정위상견적중형약물불량반응。본문대목전유관약물불량반응적유전학연구신진전진행료종술。
Harmful and unintended reactions to medicines that occur at normally used doses for treatment are called adverse drug reactions ( ADRs) . All ADRs are idiosyncratic reactions of the body to drugs. Severe adverse drug reactions ( SDAR) , including drug-induce hypersensitivity syndrome ( DHS) , Stevens-John-son syndrome ( SJS) and toxic epidermal necrolysis ( TEN) , are currently major ADRs. In this paper we fo-cus the genetic aspects of the syndrome.