CAJ | 학술논문

目的：评价蛋氨酸硒联合NB-UVB照射治疗寻常型银屑病的疗效及对血清TNF-α的影响。方法：将73例患者随机分为两组，治疗组39例，采用NB-UVB照射，隔日1次，同时口服蛋氨酸硒(100μg/片)。对照组34例，采用NB-UVB照射，隔日1次。治疗4周后观察疗效并测定血清中TNF-α和Se含量。结果：治疗组与对照组有效率分别为89.74％和70.59％，两组差异有统计学意义(P<0.05)；两组TNF-α水平治疗前后分别为1.76±0.35、1.41±0.48和1.67±0.44、1.43±0.41，治疗后均明显降低(P<0.05)，但两组间差异无统计学意义(P>0.05)。结论： Se联合NB-UVB照射治疗寻常型银屑病疗效优于单用NB-UVB照射，但对于降低TNF-α水平二者可能无协同作用。
목적：평개단안산서연합NB-UVB조사치료심상형은설병적료효급대혈청TNF-α적영향。방법：장73례환자수궤분위량조，치료조39례，채용NB-UVB조사，격일1차，동시구복단안산서(100μg/편)。대조조34례，채용NB-UVB조사，격일1차。치료4주후관찰료효병측정혈청중TNF-α화Se함량。결과：치료조여대조조유효솔분별위89.74％화70.59％，량조차이유통계학의의(P<0.05)；량조TNF-α수평치료전후분별위1.76±0.35、1.41±0.48화1.67±0.44、1.43±0.41，치료후균명현강저(P<0.05)，단량조간차이무통계학의의(P>0.05)。결론： Se연합NB-UVB조사치료심상형은설병료효우우단용NB-UVB조사，단대우강저TNF-α수평이자가능무협동작용。
Objective:To assess the efficacy of selenium methinoine ( SeMet) combined with narrow-band ultraviolet B ( NB-UVB) in the treatment of psoriasis vulgaris ( PV) and of the influence on the serum TNF-α levels. Methods:Seventy-three patients with PV were randomly divided into treatment group and control group. The patients (39) were treated with NB-UVB (every other day) and oral SeMet (twice daily). The patients ( 34) in control group were treated with NB-UVB ( every other day) and oral placebo ( twice daily) . The duration of the treatment was 4 weeks. The efficacy and the serum level of TNF-αand Se were tested. Re-sults:The total effective rate in treatment group was 89.74% and 70.59% in the control group, with a signifi-cant difference between the two groups (P<0.05). The TNF-α level after treatment was decreased in both groups ( P<0.05) , but the decreasing level was no significant difference between the two groups ( P>0.05) . Conclusion: The combination of NB-UVB with oral SeMet was more effective than NB-UVB alone in the treatment of PV. However, Se may be not a synergic factor with NB-UVB in decreasing TNF-α level.