CAJ | 학술논문

目的：确定解整合素金属蛋白酶( ADAM33)基因与东北地区汉族人群银屑病的相关性。方法：利用多重SNaPSHOT方法检测东北汉族400例银屑病患者和398名正常对照的ADAM33基因中rs2787094、rs512625、rs597980位点的基因分型。比较患者和对照组间、不同临床表型组间的基因型、等位基因和单体型频率分布的差异性。结果： ADAM33基因 rs2787094CC、CG基因型和2个单体型( H3和H5)可能为银屑病的危险因素( P<0.05)，rs512625AA基因型和3个单体型( H1、H4和H7)可能是银屑病的保护因素(P<0.05)。 rs597980的基因型和等位基因在病例和对照组间无差异(P>0.05)。rs2787094CC基因型和C等位基因可能与晚期发病和/或无家族史的患者具有相关性，与病情严重程度和性别无关。结论： ADAM33基因的多态位点与东北地区汉族人群银屑病具有相关性。
목적：학정해정합소금속단백매( ADAM33)기인여동북지구한족인군은설병적상관성。방법：이용다중SNaPSHOT방법검측동북한족400례은설병환자화398명정상대조적ADAM33기인중rs2787094、rs512625、rs597980위점적기인분형。비교환자화대조조간、불동림상표형조간적기인형、등위기인화단체형빈솔분포적차이성。결과： ADAM33기인 rs2787094CC、CG기인형화2개단체형( H3화H5)가능위은설병적위험인소( P<0.05)，rs512625AA기인형화3개단체형( H1、H4화H7)가능시은설병적보호인소(P<0.05)。 rs597980적기인형화등위기인재병례화대조조간무차이(P>0.05)。rs2787094CC기인형화C등위기인가능여만기발병화/혹무가족사적환자구유상관성，여병정엄중정도화성별무관。결론： ADAM33기인적다태위점여동북지구한족인군은설병구유상관성。
Objective: To determine the association between ADAM33 and psoriasis in the northeastern Han population. Methods:Three common single nucleotide polymorphisms ( SNPs) ( rs2787094, rs512625 and rs597980) from ADAM33 were genotyped in 400 patients with psoriasis and 398 controls from the north-eastern Han population using a Multiplex SNaPSHOT method. SNPs genotypes and alleles frequencies were an-alyzed by SPSS 13.0. Rs2787094 CC genotype and C allele were compared between the patients and controls, as well as between patients with different clinical phenotypes of psoriasis. Results:The rs2787094CC CG gen-otypes (P<0.05) and 2 haplotypes were associated with an increased risk of psoriasis (H3, H5; P<0.05). The rs512625AA genotype and 3 haplotypes ( H1, H4, H7) were found to be a protective factor against psori-asis ( P<0.05) . Rs2787094CC genotype and C allele were associated with patients both in the late onset group and/or in the sporadic group ( P<0.05) . Conclusion:ADAM33 is associated with psoriasis in the northeast-ern Han population.