CAJ | 학술논문

以2-氨基吡啶为原料，在20％（质量分数）的硫酸溶液中，通过滴加过量的10％（质量分数）的亚硝酸钠，在0~5℃左右进行重氮化反应，重氮液在 Na2 CO3溶液中水解、中和后合成2-羟基吡啶，采用结晶和重结晶的方法，得到含量为98％以上的2-羟基吡啶，产物收率可达78％左右。本方法设计的合成路线步骤简单、反应时间短、易于操作和适合工业化。
이2-안기필정위원료，재20％（질량분수）적류산용액중，통과적가과량적10％（질량분수）적아초산납，재0~5℃좌우진행중담화반응，중담액재 Na2 CO3용액중수해、중화후합성2-간기필정，채용결정화중결정적방법，득도함량위98％이상적2-간기필정，산물수솔가체78％좌우。본방법설계적합성로선보취간단、반응시간단、역우조작화괄합공업화。
2 - Hydroxypyridine was prepared by diazotization of 2 - aminopyridine,dissoving in 20% sulfuric acid solution and putting NaNO2 solution in excess of about 10% into the solution. The appropriate temperature of diazotization is 0 ~5℃ ,followed by an alkaline hydrolysis process in Na2 CO3 solution. Thus,2 - hydroxypyridine was gained together with sodium sulfate. To purify the 2 - hydroxypyridine needs methods of crystallization and recrystallization for extraction. At last high quality of 2 - hydroxypyridine was synthesized with 98% content. And the yield could be satisfied as high as 78%or so. The time needed by the route is much shorter than that of the references,and has simpler operation than others. The process is very suitable for industrial.