CAJ | 학술논문

目的：探讨健康对照组、COPD稳定期组和COPD急性加重组中hsCRP、TNF-α、IL-6、IL-8水平变化及与肺功能的相关性。方法纳入30例健康者、28例COPD稳定期患者和30例COPD急性加重期患者作为研究对象，测定EBC中 hsCRP、TNF-α、IL-6、IL-8的浓度，以及与第1秒用力呼吸量占预计值的百分比的相关分析。结果(1) COPD急性加重组中hsCRP、TNF-α、IL-6、IL-8水平高于COPD稳定期组，差异具有显著性(P<0．05)。(2)COPD稳定期组 hsCRP、TNF-α、IL-6、IL-8水平均高于对照组，差异具有显著性(P <0．05)。(3)COPD急性加重组中TNF-α、IL-6、IL-8水平均与FEV1%呈负相关(P<0．05)，而hsCRP与FEV1%则无明显相关性。结论 COPD气道炎症与hsCRP、TNF-α、IL-6、IL-8水平释放增多有关，检测EBC中hsCRP、TNF-α、IL-6、IL-8水平可作为判断COPD病情及预后的指标。
목적：탐토건강대조조、COPD은정기조화COPD급성가중조중hsCRP、TNF-α、IL-6、IL-8수평변화급여폐공능적상관성。방법납입30례건강자、28례COPD은정기환자화30례COPD급성가중기환자작위연구대상，측정EBC중 hsCRP、TNF-α、IL-6、IL-8적농도，이급여제1초용력호흡량점예계치적백분비적상관분석。결과(1) COPD급성가중조중hsCRP、TNF-α、IL-6、IL-8수평고우COPD은정기조，차이구유현저성(P<0．05)。(2)COPD은정기조 hsCRP、TNF-α、IL-6、IL-8수평균고우대조조，차이구유현저성(P <0．05)。(3)COPD급성가중조중TNF-α、IL-6、IL-8수평균여FEV1%정부상관(P<0．05)，이hsCRP여FEV1%칙무명현상관성。결론 COPD기도염증여hsCRP、TNF-α、IL-6、IL-8수평석방증다유관，검측EBC중hsCRP、TNF-α、IL-6、IL-8수평가작위판단COPD병정급예후적지표。
Objective To investigate the relationship between EBC levels of interleukin-6 (IL-6), interleu-kin-8 (IL-8), hsCRP, TNF-α and pulmonary function in patients with COPD. Methods The levels of hsCRP, TNF-α, IL-6 and IL-8 were detected from 30 cases of normal volunteers, 28 cases in stable period of COPD and 30 cases of acute exacerbation of COPD. FEV1% was correlated analyzed. Results (1) The levels of hsCRP, TNF-α, IL-6 and IL-8 in patients with AECOPD were significantly higher than those in stable period of COPD ( P<0. 05 ) . (2) The levels of hsCRP, TNF-α, IL-6 and IL-8 in patients with stable period of COPD were significantly higher than those in normal volunteers (P<0. 05). (3) The level of TNF-α, IL-6 and IL-8 in patients with AECOPD were negatively correlated with FEV1% (P<0. 05). But the level of hsCRP had no relation with FEV1%. Conclusion The increased levels of hsCRP, TNF-α, IL-6 and IL-8 play certain role in acute exacerbation of COPD, which can be indicators in judging the prognosis of COPD.