CAJ | 학술논문

目的：观察硫酸镁和酚妥拉明治疗毛细支气管炎的临床疗效。方法选择毛细支气管炎患儿148例，随机分为两组，硫酸镁组76例常规治疗基础上加用25%硫酸镁(0.1~0．3 ml·kg-1·d-1)，每天一次，连用3~5天，酚妥拉明72例组常规治疗基础上加用酚妥拉明按1~1．5μg·kg-1·min-1速度输注，微泵维持4小时，每天一次，连用3~5天。比较两组临床症状、体征持续时间，住院时间及疗效、不良反应发生率。结果硫酸镁组、酚妥拉明组在呼吸改善、缺氧改善、喘憋改善、咳嗽消失、肺部罗音消失、胸片肺部病灶吸收、住院时间两组间无显著性差异(P>0．05)；总有效率两组间无显著性差异(P>0．05)；不良反应鼻塞、烦躁、心率加快、呼吸困难加重、面色苍白、低血压酚妥拉明组明显高于硫酸镁组(P<0．01)，有显著性差异。结论小剂量硫酸镁、酚妥拉明辅佐治疗毛细支气管炎效果显著，硫酸镁组副作用相对较小，使用安全，值得临床推广。
목적：관찰류산미화분타랍명치료모세지기관염적림상료효。방법선택모세지기관염환인148례，수궤분위량조，류산미조76례상규치료기출상가용25%류산미(0.1~0．3 ml·kg-1·d-1)，매천일차，련용3~5천，분타랍명72례조상규치료기출상가용분타랍명안1~1．5μg·kg-1·min-1속도수주，미빙유지4소시，매천일차，련용3~5천。비교량조림상증상、체정지속시간，주원시간급료효、불량반응발생솔。결과류산미조、분타랍명조재호흡개선、결양개선、천별개선、해수소실、폐부라음소실、흉편폐부병조흡수、주원시간량조간무현저성차이(P>0．05)；총유효솔량조간무현저성차이(P>0．05)；불량반응비새、번조、심솔가쾌、호흡곤난가중、면색창백、저혈압분타랍명조명현고우류산미조(P<0．01)，유현저성차이。결론소제량류산미、분타랍명보좌치료모세지기관염효과현저，류산미조부작용상대교소，사용안전，치득림상추엄。
Objective To compare the clinical effect of magnesium sulfate and phentolamine in treatment of bronchiolitis. Methods 148 children with bronchiolitis were randomly divided into two groups. The magnesium sul-fate group (76 cases) took the routine treatment combined with 25% magnesium sulfate (0. 1 ~0. 3 ml·kg-1 · d-1), once a day, 3~5 days continuously. The phentolamine group (72 cases) took the routine treatment combined with phentolamine infusion with speed in 1~1. 5 μg·kg-1 ·min-1 , with the micro pump for 4 hours, once a day, lasting 3~5 days. The clinical symptoms, the duration of hospital stay, the therapeutic effect and the incidence of adverse reactions were observed between the two groups. Results There was no significant difference between the two groups in respiratory improvement, hypoxia improvement, asthmatic and breath holding symptom improvement, cough disappearing, lung rales disappearing, absorption of chest lung lesions and duration of hospital stay ( P >0. 05). The total effective rate showed no significant difference between the two groups (P>0. 05). There were sig-nificant differences in the adverse reactions of rhinobyon, irritability, heart rate acceleration, exacerbation of dyspne-a, pale complexion, hypotension, and arrhythmia. Conclusion The routine treatment combined with small dose of magnesium sulfate or phentolamine has remarkable curative effect to bronchiolitis. The magnesium sulfate group has less side effects, and it is safe and worthy of widely clinical application.