临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2014年
11期
1972-1975
,共4页
FGF21%SAS%相关性
FGF21%SAS%相關性
FGF21%SAS%상관성
FGF21%SAS%association
目的：本研究通过对318例男性参与者进行4年的随访,探讨成纤维细胞生长因子( FGF-21)与睡眠呼吸暂停综合征( sleep apnea syndrome,SAS)发生发展的关系。方法记录参与者一般临床资料,采用酶联免疫吸附法( ELISA )测定基线及随访4年后血清 FGF-21浓度水平,对比分析 SAS 组与非 SAS 组间FGF21浓度水平差异,并采用多因素Logistic回归分析FGF21是否为SAS独立危险因素。结果 SAS组基线FGF21浓度水平明显高于非SAS组,差异有统计学意义( P<0．05)；SAS组随访4年后FGF21浓度水平明显高于基线FGF21浓度水平,差异有统计学意义(P<0．05),非SAS组随访4年后血清FGF21浓度水平与基线FGF21浓度水平差异无统计学意义(P>0．05)；多因素Logistic回归分析发现BMI、TG、HOMA-IR、FGF21是影响SAS发生的独立危险因素。结论血清FGF-21浓度水平高是SAS发生的独立危险因素,未来有可能成为干预SAS有效的分子靶点。
目的：本研究通過對318例男性參與者進行4年的隨訪,探討成纖維細胞生長因子( FGF-21)與睡眠呼吸暫停綜閤徵( sleep apnea syndrome,SAS)髮生髮展的關繫。方法記錄參與者一般臨床資料,採用酶聯免疫吸附法( ELISA )測定基線及隨訪4年後血清 FGF-21濃度水平,對比分析 SAS 組與非 SAS 組間FGF21濃度水平差異,併採用多因素Logistic迴歸分析FGF21是否為SAS獨立危險因素。結果 SAS組基線FGF21濃度水平明顯高于非SAS組,差異有統計學意義( P<0．05)；SAS組隨訪4年後FGF21濃度水平明顯高于基線FGF21濃度水平,差異有統計學意義(P<0．05),非SAS組隨訪4年後血清FGF21濃度水平與基線FGF21濃度水平差異無統計學意義(P>0．05)；多因素Logistic迴歸分析髮現BMI、TG、HOMA-IR、FGF21是影響SAS髮生的獨立危險因素。結論血清FGF-21濃度水平高是SAS髮生的獨立危險因素,未來有可能成為榦預SAS有效的分子靶點。
목적：본연구통과대318례남성삼여자진행4년적수방,탐토성섬유세포생장인자( FGF-21)여수면호흡잠정종합정( sleep apnea syndrome,SAS)발생발전적관계。방법기록삼여자일반림상자료,채용매련면역흡부법( ELISA )측정기선급수방4년후혈청 FGF-21농도수평,대비분석 SAS 조여비 SAS 조간FGF21농도수평차이,병채용다인소Logistic회귀분석FGF21시부위SAS독립위험인소。결과 SAS조기선FGF21농도수평명현고우비SAS조,차이유통계학의의( P<0．05)；SAS조수방4년후FGF21농도수평명현고우기선FGF21농도수평,차이유통계학의의(P<0．05),비SAS조수방4년후혈청FGF21농도수평여기선FGF21농도수평차이무통계학의의(P>0．05)；다인소Logistic회귀분석발현BMI、TG、HOMA-IR、FGF21시영향SAS발생적독립위험인소。결론혈청FGF-21농도수평고시SAS발생적독립위험인소,미래유가능성위간예SAS유효적분자파점。
Objective To investigate the association between fibroblast growth factor 21 (FGF21) and sleep apnea syndrome ( SAS) development. Methods The clinical data of subjects were recorded, serum FGF21 levels at baseline and follow-up were measured using an enzyme-linked immunosorbent assay. Whether FGF21 was independ-ent predictor of SAS were identified using logistic regressions. Results The serum level of FGF21 was significantly higher in the SAS group than in the non-SAS group (P<0. 05). During follow-up, significant increase of FGF21 lev-el was observed in those subjects who developed SAS (P<0. 05), but in the non-SAS group, there was no significant difference in FGF21 level between baseline and follow-up. BMI, TC, HOMA-IR and FGF21 were independent pre-dictors of SAS through logistic regressions. Conclusion The high level of FGF21 is an independent predictor of SAS, which can be useful for early diagnosis and intervention of SAS.
