CAJ | 학술논문

目的：探讨proET-1在评估CAP患者严重程度及预后方面的价值。方法对我院42例CAP患者进行前瞻性研究,以同期48例健康体检者做对照,根据美国重症肺炎诊断标准,分为重症肺炎组及普通肺炎组,通过统计学处理分析不同组别间proET-1、PCT和白细胞计数差异性。结果37例普通CAP与5例重症CAP的比较,proET-1及PCT检测有统计学意义( P值分别<0．01和<0．05),而白细胞计数无统计学意义(P值>0．05)；42例CAP患者(普通+重症)与对照组比较,proET-1、PCT及白细胞计数的检测均有统计学意义(P值均<0．01)；37例普通CAP患者入院时与病情痊愈时(或病情好转时)相比较,白细胞计数及PCT检测有统计学意义(P值分别<0．001和<0．05),而proET-1无统计学意义(P值>0．05)。结论 proET-1及PCT水平和白细胞计数可以作为CAP感染的炎性标记物；proET-1及PCT血浆水平可以预测CAP患者严重程度及预后,且proET-1优于PCT。
목적：탐토proET-1재평고CAP환자엄중정도급예후방면적개치。방법대아원42례CAP환자진행전첨성연구,이동기48례건강체검자주대조,근거미국중증폐염진단표준,분위중증폐염조급보통폐염조,통과통계학처리분석불동조별간proET-1、PCT화백세포계수차이성。결과37례보통CAP여5례중증CAP적비교,proET-1급PCT검측유통계학의의( P치분별<0．01화<0．05),이백세포계수무통계학의의(P치>0．05)；42례CAP환자(보통+중증)여대조조비교,proET-1、PCT급백세포계수적검측균유통계학의의(P치균<0．01)；37례보통CAP환자입원시여병정전유시(혹병정호전시)상비교,백세포계수급PCT검측유통계학의의(P치분별<0．001화<0．05),이proET-1무통계학의의(P치>0．05)。결론 proET-1급PCT수평화백세포계수가이작위CAP감염적염성표기물；proET-1급PCT혈장수평가이예측CAP환자엄중정도급예후,차proET-1우우PCT。
Objective To investigate the value of endothelin-1 precursor peptides in evaluating the severity and prognosis of CAP. Methods 42 CAP patients were prospectively studied, compared with 48 healthy people as the control group. According to diagnosis standard of severe pneumonia in IDSAZ/ATS, they were divided into the severe pneumonia group and the ordinary pneumonia group. The differences of proET-1, PCT and white cell count were analyzed. Results In 37 cases of ordinary CAP and 5 cases of severe CAP, there was statistical significance in proET-1 and PCT respectively (P<0. 01 and P<0. 05), and there was no significant difference in white blood cell count between the two groups (P>0. 05). There were significant differences in proET-1, PCT and blood cell count between the CAP group and the control group (P<0. 01). Conclusion ProET-1 and PCT levels and leukocyte count can be used as markers of inflammation of CAP infection. ProET-1 and PCT levels may predict the severity and prognosis of CAP patients, and proET-1 is better than PCT.