CAJ | 학술논문

目的：总结单纯性肺磨玻璃样病变( pure ground-glass opacity,pGGO)的临床特征,探讨其对早期肺癌的诊断意义与最佳治疗方案。方法收集我科近五年来22例pGGO患者的临床资料,分析患者的临床特性、影像特点、手术方式、病理类型和预后。结果22例pGGO患者经过保守治疗无效后行手术治疗,术后病理明确12例为原位腺癌,8例为不典型腺瘤样增生,2例为炎性假瘤。原位腺癌直径(14±3) mm,非典型腺瘤样增生病灶直径(8±2)mm,差异有统计学意义(P<0．05)。术后随访4个月~5年,患者均生存。结论 pGGO中多数原位腺癌病灶直径大于非典型腺瘤样增生病灶。胸部CT提示直径≥10 mm、有恶性征象或含有实性成分的pGGO为早期肺癌或癌前病变,应提高警惕,尽早行胸腔镜下肺叶切除术。
목적：총결단순성폐마파리양병변( pure ground-glass opacity,pGGO)적림상특정,탐토기대조기폐암적진단의의여최가치료방안。방법수집아과근오년래22례pGGO환자적림상자료,분석환자적림상특성、영상특점、수술방식、병리류형화예후。결과22례pGGO환자경과보수치료무효후행수술치료,술후병리명학12례위원위선암,8례위불전형선류양증생,2례위염성가류。원위선암직경(14±3) mm,비전형선류양증생병조직경(8±2)mm,차이유통계학의의(P<0．05)。술후수방4개월~5년,환자균생존。결론 pGGO중다수원위선암병조직경대우비전형선류양증생병조。흉부CT제시직경≥10 mm、유악성정상혹함유실성성분적pGGO위조기폐암혹암전병변,응제고경척,진조행흉강경하폐협절제술。
Objective To summarize the clinical characteristics of pulmonary pure ground-glass opacity ( pGGO) , and to explore its meaning of diagnosis and treatment for early stage lung cancer. Methods The clinical data of 22 patients with pGGO during the five years were collected. Their clinical characteristics, radiologic charac-teristics, surgical procedures, pathological types of tumor and prognosis were analyzed. Results All 22 patients un-derwent aggressive surgical treatment after ineffective conservative treatment. Pathological examinations after operation revealed that there were 12 cases of adenocarcinoma in stiu ( AIS) , 8 cases of atypical adenomatous hyperplasia and 2 cases of inflammatory pseudoneoplasm. AIS diameter was (14 ± 3) mm, and atypical adenomatous hyperplasia di-ameter was (8 ± 2) mm. The diameters of AIS lesions were significantly longer than those of atypical adenomatous hyperplasia lesions (P<0. 05). Patients were followed-up for 4 months to 5 years, and all survived. Conclusion Video-assisted thoracoscopic sublobectomy should be applied positively for pGGO with diameter≧10mm prompted by chest CT and with malignant images.