中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
18期
106-107
,共2页
帕利哌酮%黄芪注射液%血府逐瘀胶囊%脑外伤%精神障碍%临床疗效
帕利哌酮%黃芪註射液%血府逐瘀膠囊%腦外傷%精神障礙%臨床療效
파리고동%황기주사액%혈부축어효낭%뇌외상%정신장애%림상료효
paliperidone%Huangqi Injection%Xufuzhuyu Capsule%brain trauma%mental disorders%clinical efficacy
目的：探讨帕利哌酮联合中成药治疗脑外伤所致精神障碍的临床疗效及安全性。方法将72例脑外伤致精神障碍患者随机分为对照组和观察组，各36例。对照组给予帕利哌酮缓释片治疗，观察组在对照组基础上加用黄芪注射液和血府逐瘀胶囊。于治疗前及治疗后2，4，6，8周末采用阳性与阴性症状量表（PANSS）进行评分，观察临床疗效，监测帕利哌酮的起效时间、用药剂量，记录不良反应。结果治疗8周后，观察组总有效率为97.22%，明显高于对照组的86.11%（ P <0.05）；观察组 PANSS 总分及各因子分与对照组相比均有显著下降（ P <0.05），观察组平均起效时间短于对照组，帕利哌酮日平均剂量少于对照组，不良反应发生率低于对照组，差异均有统计学意义（ P <0.05）。结论帕利哌酮联合中成药治疗脑外伤后伴躁狂的精神障碍，疗效确切，起效更快，控制症状更迅速，用药剂量少，不良反应少，值得临床推广。
目的：探討帕利哌酮聯閤中成藥治療腦外傷所緻精神障礙的臨床療效及安全性。方法將72例腦外傷緻精神障礙患者隨機分為對照組和觀察組，各36例。對照組給予帕利哌酮緩釋片治療，觀察組在對照組基礎上加用黃芪註射液和血府逐瘀膠囊。于治療前及治療後2，4，6，8週末採用暘性與陰性癥狀量錶（PANSS）進行評分，觀察臨床療效，鑑測帕利哌酮的起效時間、用藥劑量，記錄不良反應。結果治療8週後，觀察組總有效率為97.22%，明顯高于對照組的86.11%（ P <0.05）；觀察組 PANSS 總分及各因子分與對照組相比均有顯著下降（ P <0.05），觀察組平均起效時間短于對照組，帕利哌酮日平均劑量少于對照組，不良反應髮生率低于對照組，差異均有統計學意義（ P <0.05）。結論帕利哌酮聯閤中成藥治療腦外傷後伴躁狂的精神障礙，療效確切，起效更快，控製癥狀更迅速，用藥劑量少，不良反應少，值得臨床推廣。
목적：탐토파리고동연합중성약치료뇌외상소치정신장애적림상료효급안전성。방법장72례뇌외상치정신장애환자수궤분위대조조화관찰조，각36례。대조조급여파리고동완석편치료，관찰조재대조조기출상가용황기주사액화혈부축어효낭。우치료전급치료후2，4，6，8주말채용양성여음성증상량표（PANSS）진행평분，관찰림상료효，감측파리고동적기효시간、용약제량，기록불량반응。결과치료8주후，관찰조총유효솔위97.22%，명현고우대조조적86.11%（ P <0.05）；관찰조 PANSS 총분급각인자분여대조조상비균유현저하강（ P <0.05），관찰조평균기효시간단우대조조，파리고동일평균제량소우대조조，불량반응발생솔저우대조조，차이균유통계학의의（ P <0.05）。결론파리고동연합중성약치료뇌외상후반조광적정신장애，료효학절，기효경쾌，공제증상경신속，용약제량소，불량반응소，치득림상추엄。
Objective To explore the clinical efficacy and safety of paliperidone combined with Chinese patent drug in treating mental dis-orders caused by brain trauma. Methods 72 patients with mental disorders caused by brain trauma were randomly divided into the control group and the treatment group,36 cases in each group. The control group was given Paliperidone Sustained Release Tablet,while on this basis the observation group was added with Huangqi Injection and Xuefuzhuyu Capsule. The clinical efficacy was assessed before treatment and at 2,4,6,8 weeks after treatment with the Positive and Negative Syndrome Scale(PANSS). The adverse reactions were evaluated with the Treatment Emergent Symptoms Scale(TESS). The clinical effects were observed and compared between the two groups. The effect onset time,dosage,adverse reactions were recorded. Results The total effective rates after 8 - week treatment were 97. 22% in the observation group and which is significantly higher than 86. 11% in the control group( P < 0. 05);the total and each factor scores of PANSS in the observation group were significantly decreased compared with the control group( P < 0. 05). The average effect onset time in the observa-tion group was shorter than that in the control group,the average dosage of paliperidone was less than that in the control group,and the occurrence rate of adverse reactions was lower than that in the control group,the differences had statistical significance( P < 0. 05). Conclusion Paliperidone combined with Chinese patent drug for treating mental disorders caused by brain trauma has definite effect,rapid onset,rapid control of symptoms,small dose and less adverse reactions,which is worthy of clinical promotion.
