中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
18期
99-100,101
,共3页
滋水清肝汤%度洛西汀%抑郁症%疗效观察
滋水清肝湯%度洛西汀%抑鬱癥%療效觀察
자수청간탕%도락서정%억욱증%료효관찰
duloxetine%WNLC Decoction%depression%random%effect observation
目的:观察滋水清肝汤联合度洛西汀治疗抑郁症的疗效及安全性。方法将100例抑郁症患者随机分为试验组和对照组,各50例。对照组采用度洛西汀治疗,试验组采用滋水清肝汤联合度洛西汀治疗,于治疗前和治疗后第2,4,8周分别采用汉密尔顿抑郁量表(HAMD -17)、汉密尔顿焦虑量表(HAMA)、临床疗效总评量表(CGI)评价疗效,以 HAMD -17减分率为主要疗效判定指标,同时观察并记录试验期间发生的不良反应。结果试验组和对照组总有效率分别为88.00%和74.00%,差异无统计学意义,但试验组和对照组的 HAMD -17评分在治疗第2,4,8周时差异均有统计学意义( P <0.05),试验组平均评分均低于对照组( P <0.05);试验组的不良反应发生率为38.00%,显著低于对照组的64.00%( P <0.05)。结论滋水清肝汤联合度洛西汀治疗抑郁症可提高临床疗效和降低不良反应发生率,值得临床推广。
目的:觀察滋水清肝湯聯閤度洛西汀治療抑鬱癥的療效及安全性。方法將100例抑鬱癥患者隨機分為試驗組和對照組,各50例。對照組採用度洛西汀治療,試驗組採用滋水清肝湯聯閤度洛西汀治療,于治療前和治療後第2,4,8週分彆採用漢密爾頓抑鬱量錶(HAMD -17)、漢密爾頓焦慮量錶(HAMA)、臨床療效總評量錶(CGI)評價療效,以 HAMD -17減分率為主要療效判定指標,同時觀察併記錄試驗期間髮生的不良反應。結果試驗組和對照組總有效率分彆為88.00%和74.00%,差異無統計學意義,但試驗組和對照組的 HAMD -17評分在治療第2,4,8週時差異均有統計學意義( P <0.05),試驗組平均評分均低于對照組( P <0.05);試驗組的不良反應髮生率為38.00%,顯著低于對照組的64.00%( P <0.05)。結論滋水清肝湯聯閤度洛西汀治療抑鬱癥可提高臨床療效和降低不良反應髮生率,值得臨床推廣。
목적:관찰자수청간탕연합도락서정치료억욱증적료효급안전성。방법장100례억욱증환자수궤분위시험조화대조조,각50례。대조조채용도락서정치료,시험조채용자수청간탕연합도락서정치료,우치료전화치료후제2,4,8주분별채용한밀이돈억욱량표(HAMD -17)、한밀이돈초필량표(HAMA)、림상료효총평량표(CGI)평개료효,이 HAMD -17감분솔위주요료효판정지표,동시관찰병기록시험기간발생적불량반응。결과시험조화대조조총유효솔분별위88.00%화74.00%,차이무통계학의의,단시험조화대조조적 HAMD -17평분재치료제2,4,8주시차이균유통계학의의( P <0.05),시험조평균평분균저우대조조( P <0.05);시험조적불량반응발생솔위38.00%,현저저우대조조적64.00%( P <0.05)。결론자수청간탕연합도락서정치료억욱증가제고림상료효화강저불량반응발생솔,치득림상추엄。
Objective To observe the efficacy and safety of duloxetine combined with Water - Nourishing and Liver - Clearing(WNLC) Decoction in treating depression. Methods By using the randomized,parallel - controlled method,100 patients with depression were ran-domized to the experimental group and the control group,50 cases in each group. The control group was treated by duloxetine,while the treatment group adopted duloxetine combined with WNLC decoction. The efficacy before and at 2,4,8 weeks after treatment was evalu-ated by the Hamilton Depression Scale (HAMD - 17),the Hamilton Anxiety Scale(HAMA) and the Clinical Global Impression Scale (CGI),and the HAMD - 17 reductive ratio was taken as the main effect evaluation index. At the same time the adverse events occurred during the experimental period were observed and recorded. Results The total effective rates of the experimental group and the control group were 88. 00% and 74. 00% without statistically significant difference;but the difference in the overall situation of the effects had statistical significance;the HAMD - 17 scores at 2,4,8 weeks of treatment in the experimental group and the control group had statisti-cally significant difference( P < 0. 05);the occurrence rate of adverse reactions in the experimental group was 38. 00% ,which was sig-nificantly lower than 54. 00% in the control group( P < 0. 05). Conclusion WNLC Decoction combined with duloxetine in the treat-ment of depression is conducive to increase the clinical effect and reduce the occurrence rate of adverse reactions,which is worthy of clinical promotion.