中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
18期
24-25,26
,共3页
复方祛白喷雾剂%急性皮肤毒性%皮肤过敏性%皮肤刺激性
複方祛白噴霧劑%急性皮膚毒性%皮膚過敏性%皮膚刺激性
복방거백분무제%급성피부독성%피부과민성%피부자격성
Compound Qubai Sprays%acute dermal toxicity%skin allergy%skin irritation
目的：研究复方祛白喷雾剂的皮肤毒性和经皮肤用药的安全性。方法采用家兔急性皮肤毒性试验、豚鼠皮肤过敏试验、家兔皮肤刺激性试验，观察复方祛白喷雾剂经皮肤用药的急性毒性、过敏性和刺激性。结果复方祛白喷雾剂对家兔完整皮肤与破损皮肤无急性毒性反应；对豚鼠皮肤无致敏作用；对家兔破损皮肤有轻度刺激性反应，但给药48 h 后该刺激性反应消失。结论复方祛白喷雾剂无明显急性皮肤毒性，经皮肤用药的安全性良好。
目的：研究複方祛白噴霧劑的皮膚毒性和經皮膚用藥的安全性。方法採用傢兔急性皮膚毒性試驗、豚鼠皮膚過敏試驗、傢兔皮膚刺激性試驗，觀察複方祛白噴霧劑經皮膚用藥的急性毒性、過敏性和刺激性。結果複方祛白噴霧劑對傢兔完整皮膚與破損皮膚無急性毒性反應；對豚鼠皮膚無緻敏作用；對傢兔破損皮膚有輕度刺激性反應，但給藥48 h 後該刺激性反應消失。結論複方祛白噴霧劑無明顯急性皮膚毒性，經皮膚用藥的安全性良好。
목적：연구복방거백분무제적피부독성화경피부용약적안전성。방법채용가토급성피부독성시험、돈서피부과민시험、가토피부자격성시험，관찰복방거백분무제경피부용약적급성독성、과민성화자격성。결과복방거백분무제대가토완정피부여파손피부무급성독성반응；대돈서피부무치민작용；대가토파손피부유경도자격성반응，단급약48 h 후해자격성반응소실。결론복방거백분무제무명현급성피부독성，경피부용약적안전성량호。
Objective To investigate the dermal toxicity and safety of Compound Qubai Spray by topical application. Methods The rab-bit acute dermal toxicity tests,guinea pigs skin irritation test and the rabbit skin sensitization test were adopted to observed the skin a-cute toxicity,irritability and irritation of Compound Qubai Spray by topical application. Results The acute toxicity reaction of Compound Qubai Spray on intact skin and damaged skin in rabbit was not observed,so did the irritability in guinea pigs,the mild irritation of Compound Qubai Spray on rabbit damaged skin was observed,but which disappeared at 48 h after medication. Conclusion Compound Qubai Spray has no significant acute dermal toxicity and its skin topical application has good safety.
