CAJ | 학술논문

目的：了解深圳地区分枝杆菌的感染、分布状况，为临床诊断和治疗提供科学依据。方法采用基因芯片，对1096例临床疑似标本进行菌种鉴定。结果基因芯片鉴定结果阳性检出率为9．40％（103/1096）。阳性患者中有87例为结核分枝杆菌感染，另有16例为非结核分枝杆菌感染，其中脓肿分枝杆菌5例、胞内分枝杆菌3例、鸟分枝杆菌3例、偶发分枝杆菌2例、堪萨斯分枝杆菌1例、海分枝杆菌1例、戈登分枝杆菌1例。结论深圳地区分枝杆菌感染，结核分枝杆菌占84．47％，为主要发病类型；非结核分枝杆菌分离率比例已达到15．53％，其感染菌株包括7个种类，因此开展分枝杆菌菌种鉴定，明确病因，对实现个体化治疗有着重要意义。
목적：료해심수지구분지간균적감염、분포상황，위림상진단화치료제공과학의거。방법채용기인심편，대1096례림상의사표본진행균충감정。결과기인심편감정결과양성검출솔위9．40％（103/1096）。양성환자중유87례위결핵분지간균감염，령유16례위비결핵분지간균감염，기중농종분지간균5례、포내분지간균3례、조분지간균3례、우발분지간균2례、감살사분지간균1례、해분지간균1례、과등분지간균1례。결론심수지구분지간균감염，결핵분지간균점84．47％，위주요발병류형；비결핵분지간균분리솔비례이체도15．53％，기감염균주포괄7개충류，인차개전분지간균균충감정，명학병인，대실현개체화치료유착중요의의。
Objective To investigate the status and species of mycobacterial infections in Shenzhen for clinical diagnosis and treatment to provide a reliable scientific basis .Methods 1 096 of samples from patients with suspicious were detection by gene chip .Results Positive rate of microarray detection mycobacterium was 9 .40% (103/1 096) .103 cases of positive were 87 mycobac-teria by gene chip ,and 16 cases of non-tuberculosis(5 cases of M .abscessus ,3 cases of M .intracellulare ,3 cases of M .avium ,2 cases of M .fortuitum ,1 cases of M .kansas ,1 case of M .marinum ,1 case of M .gordonae .Conclusion The mycobacterial infections in Shenzhen ,tuberculosis infection as the main disease types (84 .47% ) .Non-tuberculous mycobacteria′s isolation ratio has reached 15 .53% ,including 7 kinds of species infection and one case of mixed infections .Identification of M ycobacterium by genechip have great significances for individualized treatment .