CAJ | 학술논문

目的：探讨急性心肌梗死（AMI）患者血浆脂蛋白（a）[Lp（a）]、同型半胱氨酸（Hcy），超敏C反应蛋白（hs-CRP）和肌钙蛋白I（cTnI）水平监测的临床应用。方法对162例AMI患者和165例健康体检者（对照组）进行血浆LP（a）、Hcy、hs-CRP和cTnI水平测定，并进行统计分析。结果 AMI患者治疗前的血浆LP（a）、Hcy、hs-CRP和cTnI水平与对照组比较，均显著增高（P＜0．01）。在AMI患者治疗后，与对照组比较，97例治疗好转患者血浆hs-CRP恢复至正常水平（t＝1．586，P＞0．05），而血浆cTnI水平降低明显（t＝3．322，P＜0．01）；36例治疗无效死亡患者血浆 Hcy、hs-CRP和cTnI水平均明显升高（P＜0．01）。结论血浆LP（a）、Hcy、hs-CRP和cTnI是治疗前诊断AMI有价值的指标，对患者治疗预后判断和随访最有价值的指标是血浆hs-CRP和cT nI。
목적：탐토급성심기경사（AMI）환자혈장지단백（a）[Lp（a）]、동형반광안산（Hcy），초민C반응단백（hs-CRP）화기개단백I（cTnI）수평감측적림상응용。방법대162례AMI환자화165례건강체검자（대조조）진행혈장LP（a）、Hcy、hs-CRP화cTnI수평측정，병진행통계분석。결과 AMI환자치료전적혈장LP（a）、Hcy、hs-CRP화cTnI수평여대조조비교，균현저증고（P＜0．01）。재AMI환자치료후，여대조조비교，97례치료호전환자혈장hs-CRP회복지정상수평（t＝1．586，P＞0．05），이혈장cTnI수평강저명현（t＝3．322，P＜0．01）；36례치료무효사망환자혈장 Hcy、hs-CRP화cTnI수평균명현승고（P＜0．01）。결론혈장LP（a）、Hcy、hs-CRP화cTnI시치료전진단AMI유개치적지표，대환자치료예후판단화수방최유개치적지표시혈장hs-CRP화cT nI。
Objective To explore the clinical significance of plasma LP (a) ,Hcy ,hs-CRP and cTnI concentrations in patients with AMI .Methods Plasma LP(a) ,Hcy ,hs-CRP and cTnI concentrations of 162 patients with AMI and 165 healthy people recrui-ted as control group were determined .Immunofluorescent dry quantitative method and electro-chemiluminescence immunoassay were used in the determination ,and statistical analysis were used in data comparison .Results Before treatment ,the plasma LP(a) , Hcy ,hs-CRP and cTnI concentrations in 162 AMI patients were significantly higher than those in control group (P<0 .01) .After treatment ,the plasma hs-CRP concentrations in 97 improved patients returned to normal (t=1 .586 ,P>0 .05) ,but the plasma cTnI concentrations significantly decreased (t=3 .322 ,P<0 .01) .The plasma Hcy ,hs-CRP and cTnI concentrations in 36 died patients were significantly higher(P<0 .01) .Conclusion Plasma LP(a) ,Hcy ,hs-CRP and cTnI determination were valuable for the diagno-sis of AMI patients ,the most valuable indicators for patient prognosis and follow-up were plasma hs-CRP and cTnI .