国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
18期
2462-2463
,共2页
肺癌%肿瘤标志物%神经元特异性烯醇化酶%细胞角蛋白19片段%癌胚抗原%鳞状细胞癌抗原
肺癌%腫瘤標誌物%神經元特異性烯醇化酶%細胞角蛋白19片段%癌胚抗原%鱗狀細胞癌抗原
폐암%종류표지물%신경원특이성희순화매%세포각단백19편단%암배항원%린상세포암항원
lung cancer%tumor markers%neuron specific enolase%carcinoembryonic antigen%cytokeratin-19 fragments%squamous cell carcinoma antigen
目的：探讨血清中癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）、细胞角蛋白19片段（CYFRA21-1）、鳞状细胞癌抗原（SCCA）检测对肺癌的诊断价值。方法分别测定98例肺癌患者和30例健康者血清中CEA、NSE、CYFRA21-1、SCCA的水平，计算各自的阳性率、灵敏度、特异度及准确度，并进行统计学分析。结果与对照组比较，不同病理分型肺癌各组中四种血清肿瘤标志物水平显著升高（P＜0．05）；CEA、NSE、CYFRA21-1分别在腺癌、小细胞肺癌、鳞癌中的灵敏度最高；四种血清肿瘤标志物联合检测用于诊断的灵敏度和准确度增高。结论检测肺癌患者血清CEA、NSE、CYFRA21-1、SCCA 的水平，有助于肺癌病理分型、临床诊断及鉴别诊断，CEA、NSE分别为肺腺癌、小细胞肺癌诊断的肿瘤标志物；CYFRA21-1与SCCA可作为肺鳞癌诊断的肿瘤标志物；四项肿瘤标志物的联合检测可提高诊断的灵敏度和准确度。
目的：探討血清中癌胚抗原（CEA）、神經元特異性烯醇化酶（NSE）、細胞角蛋白19片段（CYFRA21-1）、鱗狀細胞癌抗原（SCCA）檢測對肺癌的診斷價值。方法分彆測定98例肺癌患者和30例健康者血清中CEA、NSE、CYFRA21-1、SCCA的水平，計算各自的暘性率、靈敏度、特異度及準確度，併進行統計學分析。結果與對照組比較，不同病理分型肺癌各組中四種血清腫瘤標誌物水平顯著升高（P＜0．05）；CEA、NSE、CYFRA21-1分彆在腺癌、小細胞肺癌、鱗癌中的靈敏度最高；四種血清腫瘤標誌物聯閤檢測用于診斷的靈敏度和準確度增高。結論檢測肺癌患者血清CEA、NSE、CYFRA21-1、SCCA 的水平，有助于肺癌病理分型、臨床診斷及鑒彆診斷，CEA、NSE分彆為肺腺癌、小細胞肺癌診斷的腫瘤標誌物；CYFRA21-1與SCCA可作為肺鱗癌診斷的腫瘤標誌物；四項腫瘤標誌物的聯閤檢測可提高診斷的靈敏度和準確度。
목적：탐토혈청중암배항원（CEA）、신경원특이성희순화매（NSE）、세포각단백19편단（CYFRA21-1）、린상세포암항원（SCCA）검측대폐암적진단개치。방법분별측정98례폐암환자화30례건강자혈청중CEA、NSE、CYFRA21-1、SCCA적수평，계산각자적양성솔、령민도、특이도급준학도，병진행통계학분석。결과여대조조비교，불동병리분형폐암각조중사충혈청종류표지물수평현저승고（P＜0．05）；CEA、NSE、CYFRA21-1분별재선암、소세포폐암、린암중적령민도최고；사충혈청종류표지물연합검측용우진단적령민도화준학도증고。결론검측폐암환자혈청CEA、NSE、CYFRA21-1、SCCA 적수평，유조우폐암병리분형、림상진단급감별진단，CEA、NSE분별위폐선암、소세포폐암진단적종류표지물；CYFRA21-1여SCCA가작위폐린암진단적종류표지물；사항종류표지물적연합검측가제고진단적령민도화준학도。
Objective To investigate the diagnostic value of serum tumor markers carcinoembryonic antigen (CEA) ,neuron spe-cific enolase(NSE) ,cytokeratin-19 fragments(CYFRA21-1) ,squamous cell carcinoma antigen(SCCA)in the lung cancer .Methods By using electro chemiluminescence immunoassay ,the concentrations of CEA ,NSE ,CYFRA21-1 and SCCA were determined in 98 cases of lung cancer and 30 cases of healthy control group ,and the positive rate ,sensitivity ,specificity ,accuracy were calculated .Re-sults In different lung cancer pathological groups ,the concentrations of the 4 serum tumor markers were significantly higher than the control group(P<0 .05) .CEA had the highest diagnostic sensitivity for detecting adeno carcinoma ,NSE had the highest diag-nostic sensitivity for detecting small cell lung cancers ,CYFRA21-1 had the highest diagnostic sensitivity for detecting squamous carcinoma .The combined tests of four serum tumor markers had higher diagnostic sensitivity and accuracy than single test for lung cancers .Conclusion The four serum tumor markers are valuable in the pathological classification ,diagnosis and differential diagno-sis of lung cancer .The diagnostic sensitivity and the accuracy are obviously higher in combined tests .
