CAJ | 학술논문

目的：探讨检测晚期胃癌患者血清血管内皮生长因子（VEGF）、癌胚抗原（CEA）、糖类抗原19-9（CA19-9）和铁蛋白（SF）水平变化在化疗疗效评估中的价值。方法测定85例晚期胃癌患者化疗前、化疗1周期后血清VEGF、CEA、CA19-9和SF的水平；并在化疗2周期后进行疗效评价。结果化疗有效组血清VEGF、CEA、CA19-9和SF水平均较化疗前明显下降（P＜0．05）；进展组血清VEGF、CEA水平均较化疗前明显上升（P＜0．05）；稳定组血清VEGF、CEA、CA19-9、SF及进展组血清CA19-9、SF水平均较治疗前无明显变化（P＞0．05）；多重回归分析显示，血清CEA、VEGF、CA19-9水平变化与化疗疗效相关，具有统计学意义，而血清SF与化疗疗效相关性无统计学意义（t＝1．58，P＝0．119）。结论血清CEA、VEGF、CA19-9水平变化与胃癌化疗疗效相关，其检测有助于预测化疗效果。
목적：탐토검측만기위암환자혈청혈관내피생장인자（VEGF）、암배항원（CEA）、당류항원19-9（CA19-9）화철단백（SF）수평변화재화료료효평고중적개치。방법측정85례만기위암환자화료전、화료1주기후혈청VEGF、CEA、CA19-9화SF적수평；병재화료2주기후진행료효평개。결과화료유효조혈청VEGF、CEA、CA19-9화SF수평균교화료전명현하강（P＜0．05）；진전조혈청VEGF、CEA수평균교화료전명현상승（P＜0．05）；은정조혈청VEGF、CEA、CA19-9、SF급진전조혈청CA19-9、SF수평균교치료전무명현변화（P＞0．05）；다중회귀분석현시，혈청CEA、VEGF、CA19-9수평변화여화료료효상관，구유통계학의의，이혈청SF여화료료효상관성무통계학의의（t＝1．58，P＝0．119）。결론혈청CEA、VEGF、CA19-9수평변화여위암화료료효상관，기검측유조우예측화료효과。
Objective To investigate the values of serum vascular endothelial growth factor (VEGF) ,carcinoembryonic antigen (CEA) ,carbohydrate antigen 19-9 (CA19-9) and ferritin (SF) determination in assessing the efficacy of chemotherapy in patients with advanced gastric cancer .Methods Wedetermined the concentrations of serum VEGF ,CEA ,CA19-9 and SF for 85 patients with advanced gastric cancer ,before and after 1 cycles of chemotherapy and evaluated the the effect of chemotherapy after 2 cycle of chemotherapy .Results In effective group ,serum concentrations of VEGF ,CEA ,CA19-9 and SF significantly decreased after chem-otherapy cycle(P< 0 .05) ,serum VEGF and CEA concentrations significantly increased in progress group (P< 0 .05) ,serum VEGF ,CEA ,CA19-9 and SF concentrations in stable group and serum CA19-9 and SF concentrations in progress group did not change significantly(P> 0 .05) ,compared with those before chemotherapy cycle .Multiple regression analysis showed that serum CEA ,VEGF ,CA19-9 concentration changes correlated with chemotherapy efficiency ,while serum SF didn′t(t=1 .58 ,P=0 .119) . Conclusion Serum CEA ,VEGF ,CA19-9 concentration changes associated with gastric cancer chemotherapy efficiency ,which help predict the efficiency of chemotherapy .