CAJ | 학술논문

目的：探讨肺炎衣原体、幽门螺杆菌、人类巨细胞病毒三种病原微生物的慢性感染与冠状动脉病变程度的关系，从而评价三者的抗体和超敏C反应蛋白（hs-CRP）检测对冠状动脉病变监测的价值。方法经冠状动脉造影证实冠状动脉没有明显狭窄者入选对照组，共37例；有一支血管狭窄者入选单支病变组，共36例；有两支血管狭窄者入选双支病变组，共30例；有大于两支血管狭窄者入选多支病变组，共29例。对四组纳入研究者分别进行血清肺炎衣原体、幽门螺杆菌、人类巨细胞病毒的IgG抗体及hs-CRP水平检测。结果对照组、单支病变组、双支病变组、多支病变组的肺炎衣原体、幽门螺杆菌、人类巨细胞病毒的IgG抗体阳性率及混合感染率之间的差异有统计学意义（P＜0．05），IgG抗体滴度及hs-CRP浓度水平依次呈递增趋势，四组之间有统计学差异（P＜0．05）。logistic回归分析表明三种微生物抗体阳性是冠状动脉病变发生、发展的危险因素。结论三种微生物的慢性感染对冠状动脉病变的发生及发展有一定影响。
목적：탐토폐염의원체、유문라간균、인류거세포병독삼충병원미생물적만성감염여관상동맥병변정도적관계，종이평개삼자적항체화초민C반응단백（hs-CRP）검측대관상동맥병변감측적개치。방법경관상동맥조영증실관상동맥몰유명현협착자입선대조조，공37례；유일지혈관협착자입선단지병변조，공36례；유량지혈관협착자입선쌍지병변조，공30례；유대우량지혈관협착자입선다지병변조，공29례。대사조납입연구자분별진행혈청폐염의원체、유문라간균、인류거세포병독적IgG항체급hs-CRP수평검측。결과대조조、단지병변조、쌍지병변조、다지병변조적폐염의원체、유문라간균、인류거세포병독적IgG항체양성솔급혼합감염솔지간적차이유통계학의의（P＜0．05），IgG항체적도급hs-CRP농도수평의차정체증추세，사조지간유통계학차이（P＜0．05）。logistic회귀분석표명삼충미생물항체양성시관상동맥병변발생、발전적위험인소。결론삼충미생물적만성감염대관상동맥병변적발생급발전유일정영향。
Objective To study the correlation between chronic infection of three microorganism and coronary artery lesion by detecting their antibodies and high-sensitivity C-reactive protein(hs-CRP) .Methods According to their severity of coronary artery lesion ,patients enrolled in the study were divided into 4 groups ,including normal control group(n=37) ,single-branch lesion group (n=36) ,double-branch lesion group(n= 30) and multi-branch lesion group(n= 29) .Serum Chlamydia pneumonia IgG(CPN-IgG) ,Helicobacter pylori IgG(HP-IgG) ,human cytomegalo virus IgG (HCMV-IgG) and hs-CRP tests were performed .Results CPN-IgG ,HP-IgG ,HCMV-IgG positive rates and the mixed infection positive rates increased sequentially from normal group to multi-branch group .There were significant differences of CPN-IgG ,HP-IgG ,HCMV-IgG and hs-CRP contents among the 4 groups (P<0 .05) .Logistic analysis showed that CPN-IgG ,HP-IgG and HCMV-IgG were dangerous factors to coronary artery lesion . Conclusion Chronic infections of three microorganism might affect the development of coronary artery lesion .