国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2014年
18期
2453-2454,2456
,共3页
郭妮%王为民%颜新%苏庆建%韦美娟%杨丽
郭妮%王為民%顏新%囌慶建%韋美娟%楊麗
곽니%왕위민%안신%소경건%위미연%양려
糖尿病周围神经病变%氧化应激%超氧化物歧化酶
糖尿病週圍神經病變%氧化應激%超氧化物歧化酶
당뇨병주위신경병변%양화응격%초양화물기화매
diabetic peripheral neuropathy%oxidative stress%superoxide dismutase
目的：探讨血清超氧化物歧化酶（SOD）活性在2型糖尿病（T2DM ）周围神经病变检测中的临床应用价值。方法选取125例T2DM周围神经病变患者及125例健康者，用邻苯三酚比色法测定其血清SOD活性。比较 T2DM 周围神经病变患者与健康者血清SOD活性，分析T2DM周围神经病变患者血清SOD活性与患者性别、年龄及血糖水平的关系。结果 T2DM周围神经病变组血清SOD活性与对照组比较差异有统计学意义（t＝7．798，P＝0．000）。T2DM 周围神经病变患者血清SOD活性与患者性别、年龄无关；血糖水平6．1～＜7．0 mmol/L、≥7．0 mmol/L 组患者间SOD活性的比较，差异有统计学意义（ P＝0．034）。结论 T2DM周围神经病变患者血清SOD活性水平增高且与血糖水平有关，可能随血糖水平升高而增高。
目的：探討血清超氧化物歧化酶（SOD）活性在2型糖尿病（T2DM ）週圍神經病變檢測中的臨床應用價值。方法選取125例T2DM週圍神經病變患者及125例健康者，用鄰苯三酚比色法測定其血清SOD活性。比較 T2DM 週圍神經病變患者與健康者血清SOD活性，分析T2DM週圍神經病變患者血清SOD活性與患者性彆、年齡及血糖水平的關繫。結果 T2DM週圍神經病變組血清SOD活性與對照組比較差異有統計學意義（t＝7．798，P＝0．000）。T2DM 週圍神經病變患者血清SOD活性與患者性彆、年齡無關；血糖水平6．1～＜7．0 mmol/L、≥7．0 mmol/L 組患者間SOD活性的比較，差異有統計學意義（ P＝0．034）。結論 T2DM週圍神經病變患者血清SOD活性水平增高且與血糖水平有關，可能隨血糖水平升高而增高。
목적：탐토혈청초양화물기화매（SOD）활성재2형당뇨병（T2DM ）주위신경병변검측중적림상응용개치。방법선취125례T2DM주위신경병변환자급125례건강자，용린분삼분비색법측정기혈청SOD활성。비교 T2DM 주위신경병변환자여건강자혈청SOD활성，분석T2DM주위신경병변환자혈청SOD활성여환자성별、년령급혈당수평적관계。결과 T2DM주위신경병변조혈청SOD활성여대조조비교차이유통계학의의（t＝7．798，P＝0．000）。T2DM 주위신경병변환자혈청SOD활성여환자성별、년령무관；혈당수평6．1～＜7．0 mmol/L、≥7．0 mmol/L 조환자간SOD활성적비교，차이유통계학의의（ P＝0．034）。결론 T2DM주위신경병변환자혈청SOD활성수평증고차여혈당수평유관，가능수혈당수평승고이증고。
Objective To study the relationship between type 2 diabetes peripheral neuropathy and the activity of serum super-oxide dismutase(SOD) ,and the relationship between the activity of serum SOD and gender ,age ,and blood glucose concentrations in patients with type 2 diabetes peripheral neuropathy .Methods One hundred and twenty-five T2DM patients with diabetic peripheral neuropathy(DPN) and 125 healthy individuals were enrolled in the study .The pyrogallol autoxidation method were used to deter-mine the the activity of serum SOD ,and then the differences of serum SOD activity were compared between the 2 group of people . The relationship between the activity of serum SOD and gender ,age ,and blood glucose concentrations in patients with type 2 diabe-tes peripheral neuropathy were analyzed .Results The difference of the activity of serum SOD between type 2 diabetes peripheral neuropathy group and control group was statistically significant (t=7 .798 ,P=0 .000) .There were no differences between the ac-tivity of serum SOD and gender ,age ,and blood glucose concentrations in patients with type 2 diabetes peripheral neuropathy .The SOD activities in 6 .1-7 .0 mmol/L and ≥7 .0 mmol/L groups were statistically significant (P=0 .034) .Conclusion The activity of serum SOD increase in T2DM patients with DPN .The activity of serum SOD is associated with blood glucose concentrations ,and might increase with elevated blood glucose .
