CAJ | 학술논문

目的：了解医院2011～2013年临床分离的426株屎肠球菌和221株粪肠球菌的耐药性。方法采用生物梅里埃公司的VITEK2 COMPACT全自动微生物分析仪对菌株进行鉴定和抗菌药物敏感性测定。结果屎肠球菌与粪肠球菌检出数量的比值为1．93，该比值近3年呈现逐渐上升的趋势。屎肠球菌和粪肠球菌对万古霉素、利奈唑烷和替加环素的敏感率均为100．00％，屎肠球菌除对喹奴普汀/达福普汀和四环素的敏感率显著高于粪肠球菌外（ P＜0．05），对呋喃妥因、氨苄西林、青霉素G、莫西沙星、环丙沙星、左氧氟沙星的敏感率均显著低于粪肠球菌（P＜0．05）。结论肠球菌的检出呈现向屎肠球菌偏移的现象，且该现象呈现扩大的趋势。屎肠球菌和粪肠球菌对抗菌药物的敏感性存在较大差异，临床应根据两种细菌各自的特征结合种间耐药性差异制订治疗方案，目前万古霉素、利奈唑烷、替加环素为治疗屎肠球菌和粪肠球菌感染的最有效的抗菌药物。
목적：료해의원2011～2013년림상분리적426주시장구균화221주분장구균적내약성。방법채용생물매리애공사적VITEK2 COMPACT전자동미생물분석의대균주진행감정화항균약물민감성측정。결과시장구균여분장구균검출수량적비치위1．93，해비치근3년정현축점상승적추세。시장구균화분장구균대만고매소、리내서완화체가배소적민감솔균위100．00％，시장구균제대규노보정/체복보정화사배소적민감솔현저고우분장구균외（ P＜0．05），대부남타인、안변서림、청매소G、막서사성、배병사성、좌양불사성적민감솔균현저저우분장구균（P＜0．05）。결론장구균적검출정현향시장구균편이적현상，차해현상정현확대적추세。시장구균화분장구균대항균약물적민감성존재교대차이，림상응근거량충세균각자적특정결합충간내약성차이제정치료방안，목전만고매소、리내서완、체가배소위치료시장구균화분장구균감염적최유효적항균약물。
Objective To explore the sensitivity of Enterococcus f aecium and Enterococcus f aecalis isolated from 2011 to 2013 and provide reference for anti-infection therapy .Methods The identification and drug sensitivity test of clinical isolates were carried out by using VITEK2 Compact system .Results The ratio of Enterococcus f aecium to Enterococcus f aecalis isolates was 1 .93 and it was increasing year by year .No vancomycin ,linezolid and tigecycline resistant Enterococcus f aecium and Enterococcus f aecalis i-solates was detected .The rates of Enterococcus f aecium sensitive to quinupristin-dalfopristin and tetracycline were higher than En-terococcus f aecalis(P<0 .05) ,and the rates of Enterococcus f aecium sensitive to nitrofurantoin ,ampicillin ,penicillin G ,moxifloxa-cin ,levofloxacin and ciprofloxacin were lower than that of Enterococcus f aecalis(P<0 .05) .Conclusion The detection rates of En-terococcus was shifting to Enterococcus f aecium ,and the trends became obvious year after year .The drug sensitivity of Enterococcus f aecium and Enterococcus f aecalis is different ,and doctors should choose the proper therapy according to their specific drug resist-ance .At present ,vancomycin ,linezolid and tigecycline are preffered for the treatment against infection caused by Enterococcus f aeci-um and Enterococcus f aecalis .