CAJ | 학술논문

目的：探讨血脂相关指标、超敏C反应蛋白（hs-CRP）、纤维蛋白原（FIB）和D-二聚体水平与脑梗死发病的相关性。方法选取脑梗死患者259例（脑梗死组），同期健康体检者210例作为对照组。采用酶比色法测定血脂相关指标[总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白（Apo）A1、ApoB、ApoE]水平；采用荧光免疫干式定量法测定hs-CRP ；用凝固法检测FIB ；采用免疫比浊法测定D-二聚体水平。结果与对照组相比，脑梗死患病组TG、LDL-C、ApoA1、ApoE、hs-CRP、D-二聚体及FIB水平均显著升高（P＜0．01），而 HDL-C水平则显著降低（P＜0．01），TC与A poB水平差异无统计学意义（ P＞0．05）。结论炎症、血脂、凝血与纤溶系统可相互影响，并与脑梗死的发生和发展关系密切，联合检测有助于辅助诊断脑梗死。
목적：탐토혈지상관지표、초민C반응단백（hs-CRP）、섬유단백원（FIB）화D-이취체수평여뇌경사발병적상관성。방법선취뇌경사환자259례（뇌경사조），동기건강체검자210례작위대조조。채용매비색법측정혈지상관지표[총담고순（TC）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）、재지단백（Apo）A1、ApoB、ApoE]수평；채용형광면역간식정량법측정hs-CRP ；용응고법검측FIB ；채용면역비탁법측정D-이취체수평。결과여대조조상비，뇌경사환병조TG、LDL-C、ApoA1、ApoE、hs-CRP、D-이취체급FIB수평균현저승고（P＜0．01），이 HDL-C수평칙현저강저（P＜0．01），TC여A poB수평차이무통계학의의（ P＞0．05）。결론염증、혈지、응혈여섬용계통가상호영향，병여뇌경사적발생화발전관계밀절，연합검측유조우보조진단뇌경사。
Objective To study the lipids related indicators ,high-sensitivity C-reactive protein(hs-CRP) ,FIB and D-dimer levels in cerebral infarction patients .Methods 259 cerebral infraction patients(cerebral infraction group) and 210 healthy individuals(con-trol group) were enrolled in the study .Plasma lipids related indicators such as TC ,TG ,HDL-C ,LDL-C ,ApoA1 ,ApoB ,ApoE levels were measured by enzymatic colorimetric assay .Quantitative fluorescence immunoassay was used to determine serum level of hs-CRP .FIB levels were determined by using coagulation method ,and D-dimer levels by using immune turbidimetric method .Results Compared with the control group ,the TG ,LDL-C ,ApoA1 ,ApoE and hs-CRP levels were significantly higher in the cerebral infarc-tion group(P<0 .01) ,however ,the HDL-C level decreased significantly (P<0 .01) .For TC and ApoB levels ,there were no statis-tical differences between the two groups(P>0 .05) .Conclusion Lipids ,inflammation ,coagulation and fibrinolysis are closely relat-ed in the development of cerebral infarction ,and combined detection helps diagnose cerebral infarction .