CAJ | 학술논문

目的：调查兰州地区家族性高脂蛋白血症家系，了解该地区家族性高脂蛋白血症家系的特点。方法调查资料来自该课题的前期研究，筛选符合标准的高脂蛋白血症家系，收集入选家系成员调查表、体检及实验室数据，分析家族性高脂蛋白血症家系的特点。结果筛选出家族性高脂蛋白血症家系39个，共计280个家系成员。核心家系15个，单亲家系11个，父母双亡家系13个；家族性高胆固醇家系6个，家族性高三酰甘油血症家系9个，家族性混合型高脂血症家系24个。39个家系中子一代人数占全部家系所有成员的比例为63．2％，父辈所占比例为14．3％，子二代所占比例为22．5％。结论最常见的家族性高脂蛋白血症是家族性混合型高脂血症家系；血脂异常者中以子一代成员为主；核心家系数量少，不完整的非核心家系所占比例增加。
목적：조사란주지구가족성고지단백혈증가계，료해해지구가족성고지단백혈증가계적특점。방법조사자료래자해과제적전기연구，사선부합표준적고지단백혈증가계，수집입선가계성원조사표、체검급실험실수거，분석가족성고지단백혈증가계적특점。결과사선출가족성고지단백혈증가계39개，공계280개가계성원。핵심가계15개，단친가계11개，부모쌍망가계13개；가족성고담고순가계6개，가족성고삼선감유혈증가계9개，가족성혼합형고지혈증가계24개。39개가계중자일대인수점전부가계소유성원적비례위63．2％，부배소점비례위14．3％，자이대소점비례위22．5％。결론최상견적가족성고지단백혈증시가족성혼합형고지혈증가계；혈지이상자중이자일대성원위주；핵심가계수량소，불완정적비핵심가계소점비례증가。
Objective To investigate familial hyperlipoproteinemia and the features of familial hyperlipoproteinemia in Lanzhou . Methods Data were from previous studies on the subject .Families of hyperlipoproteinemia were screening ,questionnaires were col-lected ,physical examination and laboratory data of family members were also colleted to analysis the characteristics of familial hy-perlipoproteinemia .Results A total of 39 familial hyperlipoproteinemia families were enrolled in the study ,including 280 family members .There were 15 core families ,11 single-parent families ,and 13 orphaned families .There were 6 familial hypercholesterol-emia families ,9 familial hypertriglycerides families ,24 mixed familial hyperlipidemia families .The children of the first generation ac-counted for 63 .2% of the total number of people enrolled in the study ,the father generation accounted for 14 .3% ,the children of the second geration accounted for 22 .5% .Conclusion In the survey ,the most common type of familial hyperlipidemia was mixed familial hyperlipidemia .The father generation was majority .The member of core families was less than incomplete families .