CAJ | 학술논문

目的：了解急性呼吸道感染（A RI ）患儿呼吸道病毒和非典型病原体感染的情况。方法收集17048例拟诊断为ARI患儿的血清，采用间接免疫荧光法（IFA）检测9种常见的病毒和非典型病原体，包括肺炎支原体（MP）、乙型流感病毒（FluB）、呼吸道合胞病毒（RSV）、副流感病毒（PIV）、腺病毒（ADV）、甲型流感病毒（FluA）、嗜肺军团菌（LPN）、Q 热立克次体（COX）、肺炎衣原体（CPn）的IgM抗体。结果9种病原体的总体检出率为60．24％（10269/17048）。其中，MP的检出率最高，为47．78％（8146/17048），其次是FluB ，检出率为30．87％（5262/17048）。M P各季节检出率都较高；FluB主要在夏季和冬春季有小流行；RSV在冬春季检出率较高；ADV春季检出率较高；FluA在春夏季出现了小流行；PIV和LPN季节性不明显。ADV、CPn、FluA、FluB、LPN、MP、PIV、RSV 病原体检出率在各年龄组之间差异有统计学意义（P＜0．05）。2种病原体混合感染以M P＋FluB最多，占39．58％；3种病原体混合感染以M P＋FluB＋RSV多见，占13．68％。4种病原体混合感染，以M P＋ FluB＋RSV＋PIV居多，占3．84％。其他混合感染模式的阳性例数较少。结论武汉地区引起儿童ARI的病毒和非典型病原体主要是M P、FluB和RSV ；各种病原体检出率具有一定季节性且不同年龄段间有一定差异；混合感染比较普遍，主要是M P＋FluB混合感染。
목적：료해급성호흡도감염（A RI ）환인호흡도병독화비전형병원체감염적정황。방법수집17048례의진단위ARI환인적혈청，채용간접면역형광법（IFA）검측9충상견적병독화비전형병원체，포괄폐염지원체（MP）、을형류감병독（FluB）、호흡도합포병독（RSV）、부류감병독（PIV）、선병독（ADV）、갑형류감병독（FluA）、기폐군단균（LPN）、Q 열립극차체（COX）、폐염의원체（CPn）적IgM항체。결과9충병원체적총체검출솔위60．24％（10269/17048）。기중，MP적검출솔최고，위47．78％（8146/17048），기차시FluB ，검출솔위30．87％（5262/17048）。M P각계절검출솔도교고；FluB주요재하계화동춘계유소류행；RSV재동춘계검출솔교고；ADV춘계검출솔교고；FluA재춘하계출현료소류행；PIV화LPN계절성불명현。ADV、CPn、FluA、FluB、LPN、MP、PIV、RSV 병원체검출솔재각년령조지간차이유통계학의의（P＜0．05）。2충병원체혼합감염이M P＋FluB최다，점39．58％；3충병원체혼합감염이M P＋FluB＋RSV다견，점13．68％。4충병원체혼합감염，이M P＋ FluB＋RSV＋PIV거다，점3．84％。기타혼합감염모식적양성례수교소。결론무한지구인기인동ARI적병독화비전형병원체주요시M P、FluB화RSV ；각충병원체검출솔구유일정계절성차불동년령단간유일정차이；혼합감염비교보편，주요시M P＋FluB혼합감염。
Objective To investigete the viral and atypical pathogens in children with acute respiratory infection (ARI) .Methods A total of 17 048 serum samples were collected from children ,who were intended to diagnose as ARI .Indirect immunofluores-cence assays were performed to detect IgM antibodies against 9 common pathogens ,including mycoplasma pneumonia(MP) ,influen-za virus B(FluB) ,respiratory syncytial virus(RSV) ,parainfluenza virus(PIV) ,adenovirus(ADV) ,influenza A virus(FluA) ,legio-nella pneumophila(LPN) ,coxiella burnetii(COX) ,chamydophila pneumonia(CPn) .Results The total detection rate of the 9 patho-gens was 60 .24% (10 269/17 048) .The detection rate of MP was 47 .78% (8 146/17 048) which was the highest ,followed by FluB which was 30 .87% (5 262/17 048) .The detection rate of MP kept at a high level through the whole year ;FluB appeared a little popular in the summer ,winter and spring ;RSV had higher detection rate in winter and spring ;ADV had higher detection rate in spring ;FluA appeared a little popular in spring and summer ;PIV and LPN didn′t show any seasonal change .There were significant differences in the detection rates of ADV ,CPn ,FluA ,FluB ,LPN ,MP ,PIV and RSV among different age groups (P< 0 .05) .In mixed infection with 2 kinds of pathogens ,MP+FluB was the most common pattern which accounted for 39 .58% of mixed infec-tion .In mixed infection with 3 kinds of pathogens ,MP+FluB+RSV was the most common pattern which accounted for 13 .68% .In mixed infection with 4 kinds of pathogens ,MP+ FluB+ RSV+ PIV was the most common pattern which accounted for 3 .84% . Other mixed infection pattern was rare .Conclusion The most common pathogens causing ARI in children of Wuhan were MP ,FluB and RSV .The detection rate of each pathogen displayed specific seasonal variations and variations among different age groups . Mixed infections were more common than single infections ,and the most common pattern was MP+ FluB .