CAJ | 학술논문

目的：研究共济失调毛细血管扩张征突变（ATM）蛋白在早期食管鳞癌癌变组织及其癌旁正常组织中的表达差异，初步探讨其在早期食管鳞癌诊断中的意义。方法采用免疫组织化学SP法，检测ATM蛋白在早期食管鳞癌癌变组织及其癌旁正常组织中的表达，采用统计学方法分析其表达差异。结果ATM蛋白在早期食管鳞癌癌变组织及其癌旁正常组织中的阳性表达率分别是65％、95％，差异有统计学意义（P＝0．044）。结论ATM蛋白在食管鳞癌癌变组织中的表达下降，检测食管鳞癌癌变组织的ATM蛋白表达可能成为早期诊断食管鳞癌的方法。
목적：연구공제실조모세혈관확장정돌변（ATM）단백재조기식관린암암변조직급기암방정상조직중적표체차이，초보탐토기재조기식관린암진단중적의의。방법채용면역조직화학SP법，검측ATM단백재조기식관린암암변조직급기암방정상조직중적표체，채용통계학방법분석기표체차이。결과ATM단백재조기식관린암암변조직급기암방정상조직중적양성표체솔분별시65％、95％，차이유통계학의의（P＝0．044）。결론ATM단백재식관린암암변조직중적표체하강，검측식관린암암변조직적ATM단백표체가능성위조기진단식관린암적방법。
Objective To study expression differences of the ataxia telangiectasia mutated (ATM ) protein in early esophageal squamous cell carcinoma tissues and adjacent normal tissues in order to explore its diagnostic significance for early esophageal squa-mous cell carcinoma .Methods ATM protein expression was detected in early esophageal squamous cell carcinoma tissues and adja-cent normal tissues by immunohistochemical SP method and the differential expression was calculated by using statistical methods . Results The positive positive expression rate of ATM protein in the early esophageal squamous cell carcinoma tissue and adjacent normal tissue were 65% and 95% respectively ,which were statistically different (P= 0 .044) .Conclusion The ATM protein ex-pression in esophageal squamous cell carcinoma tissue declined .The detection of ATM protein in esophageal squamous cell carcino-ma tissue could become a reliable method for early diagnose of esophageal squamous cell carcinoma .