中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2014年
26期
118-120,124
,共4页
程霄霄%卢素娟%林敏%朱再胜
程霄霄%盧素娟%林敏%硃再勝
정소소%로소연%림민%주재성
非酒精性脂肪肝%二甲双胍%综合性健康教育
非酒精性脂肪肝%二甲雙胍%綜閤性健康教育
비주정성지방간%이갑쌍고%종합성건강교육
Non-alcoholic fatty liver%Metformin%Comprehensive health education
目的：探讨综合性健康教育对还原型谷胱甘肽联合二甲双胍治疗非酒精性脂肪肝疗效的影响。方法选择2012年1月~2014年1月我院收治的非酒精性脂肪肝患者64例，随机分为干预组和对照组,两组均予还原型谷胱甘肽片，每次1片，3次/d；二甲双胍片每次1片，3次/d。疗程6个月，对照组实施对症护理，干预组实施综合性健康教育，比较两组治疗后的疗效及两组患者治疗前后ALT、AST、TC、TG、BMI水平变化情况及两组患者治疗后体重指数>23 kg/m2的异常率、腰围≥80cm异常率、血脂异常率、肝功能异常率、超声结果异常率。结果干预组治疗后总有效率达93.8%，显著高于对照组的71.9%，差异有统计学意义(P<0.05)。治疗后，干预组患者的ALT、AST、TC、TG、BMI水平均较治疗前显著降低，且干预组患者的ALT、AST、TC、TG、BMI水平均明显低于对照组，差异有统计学意义(P<0.05)。干预组患者体重指数>23kg/m2的异常率、腰围≥80cm异常率、血脂异常率、肝功能异常率、超声结果异常率明显低于对照组，差异有统计学意义(P<0.05)。结论综合性健康教育可提高还原型谷胱甘肽联合二甲双胍治疗非酒精性脂肪肝的疗效，改善临床症状、降低血脂及改善肝功能，值得推广和应用。
目的：探討綜閤性健康教育對還原型穀胱甘肽聯閤二甲雙胍治療非酒精性脂肪肝療效的影響。方法選擇2012年1月~2014年1月我院收治的非酒精性脂肪肝患者64例，隨機分為榦預組和對照組,兩組均予還原型穀胱甘肽片，每次1片，3次/d；二甲雙胍片每次1片，3次/d。療程6箇月，對照組實施對癥護理，榦預組實施綜閤性健康教育，比較兩組治療後的療效及兩組患者治療前後ALT、AST、TC、TG、BMI水平變化情況及兩組患者治療後體重指數>23 kg/m2的異常率、腰圍≥80cm異常率、血脂異常率、肝功能異常率、超聲結果異常率。結果榦預組治療後總有效率達93.8%，顯著高于對照組的71.9%，差異有統計學意義(P<0.05)。治療後，榦預組患者的ALT、AST、TC、TG、BMI水平均較治療前顯著降低，且榦預組患者的ALT、AST、TC、TG、BMI水平均明顯低于對照組，差異有統計學意義(P<0.05)。榦預組患者體重指數>23kg/m2的異常率、腰圍≥80cm異常率、血脂異常率、肝功能異常率、超聲結果異常率明顯低于對照組，差異有統計學意義(P<0.05)。結論綜閤性健康教育可提高還原型穀胱甘肽聯閤二甲雙胍治療非酒精性脂肪肝的療效，改善臨床癥狀、降低血脂及改善肝功能，值得推廣和應用。
목적：탐토종합성건강교육대환원형곡광감태연합이갑쌍고치료비주정성지방간료효적영향。방법선택2012년1월~2014년1월아원수치적비주정성지방간환자64례，수궤분위간예조화대조조,량조균여환원형곡광감태편，매차1편，3차/d；이갑쌍고편매차1편，3차/d。료정6개월，대조조실시대증호리，간예조실시종합성건강교육，비교량조치료후적료효급량조환자치료전후ALT、AST、TC、TG、BMI수평변화정황급량조환자치료후체중지수>23 kg/m2적이상솔、요위≥80cm이상솔、혈지이상솔、간공능이상솔、초성결과이상솔。결과간예조치료후총유효솔체93.8%，현저고우대조조적71.9%，차이유통계학의의(P<0.05)。치료후，간예조환자적ALT、AST、TC、TG、BMI수평균교치료전현저강저，차간예조환자적ALT、AST、TC、TG、BMI수평균명현저우대조조，차이유통계학의의(P<0.05)。간예조환자체중지수>23kg/m2적이상솔、요위≥80cm이상솔、혈지이상솔、간공능이상솔、초성결과이상솔명현저우대조조，차이유통계학의의(P<0.05)。결론종합성건강교육가제고환원형곡광감태연합이갑쌍고치료비주정성지방간적료효，개선림상증상、강저혈지급개선간공능，치득추엄화응용。
Objective To investigate the effects of comprehensive health education for glutathione combined with met-formin in treatment of nonalcoholic fatty liver. Methods A total of 64 patients with nonalcoholic fatty liver from Jan-uary 2012 to January 2014 in our hospital, two groups were treated glutathione tablets, one tablet each time, 3 times every day; metformin tablets, one tablet each time, 3 times every day. The total courses were six months. All patients were randomly divided into intervention group and control group, the control group took random symptomatic care, the intervention group implemented a comprehensive health education interventions, the efficacy and the two groups of pa-tients after treatment ALT,AST, TC, TG, BMI levels, and BMI> 23kg/m2 abnormal rate, the rate of abnormal waist cir-cumference ≥80 cm, dyslipidemia, abnormal liver function rate, rate of abnormal ultrasound findings were compared between two groups. Results After treatment, the effective rate of the intervention group was 93.8%, was significantly higher than the control group 71.9%, the difference was statistically significant (P <0.05). After treatment, the ALT, AST, TC, TG, BMI levels of the intervention group were significantly lower than before treatment, and the ALT, AST, TC, TG, BMI of intervention group was significantly lower than the control group (P<0.05). BMI>23 kg/m2 abnormal rate, waist circumference≥80 cm abnormal rate, dyslipidemia, abnormal liver function rate, abnormal ultrasound results of intervention group were significantly lower than the control group,the difference was significant(P<0.05). Conclusion The comprehensive sexual health education can improve the effect of glutathione combined with metformin therapy in patients with non-alcoholic fatty liver, improve clinical symptoms, reduce blood fat and improve liver function, worthy of promotion and application.
