CAJ | 학술논문

目的：观察依帕司他治疗糖尿病感觉神经病变的临床疗效。方法选择2型糖尿病周围神经病变患者34例。测定治疗前后腓总神经及胫总神经传导速度。结果61%的受试者治疗前腓总神经感觉神经传导速度减慢，治疗后32%的受试者该神经传导速度减慢；97%的受试者治疗前胫总神经感觉神经段1传导速度减慢，治疗后65%的受试者该神经传导速度减慢；腓总神经感觉神经治疗后其神经传导速度较治疗前明显增快，胫总神经感觉神经运动节段1在治疗后其神经传导速度较治疗前明显增快。结论口服依帕司他是治疗糖尿病周围神经病变的有效手段之一。
목적：관찰의파사타치료당뇨병감각신경병변적림상료효。방법선택2형당뇨병주위신경병변환자34례。측정치료전후비총신경급경총신경전도속도。결과61%적수시자치료전비총신경감각신경전도속도감만，치료후32%적수시자해신경전도속도감만；97%적수시자치료전경총신경감각신경단1전도속도감만，치료후65%적수시자해신경전도속도감만；비총신경감각신경치료후기신경전도속도교치료전명현증쾌，경총신경감각신경운동절단1재치료후기신경전도속도교치료전명현증쾌。결론구복의파사타시치료당뇨병주위신경병변적유효수단지일。
Objective This study observed the clinical curative effects of aldose reductase inhibitor epalrestat in treat-ment of diabetic sensory neuropathy. Methods Thirty-four diabetic sensory neuropathy patients were selected. The nerve electrophysiological data were collected before and after treating with epalrestat. Results The ratios of nerve con-ductive velocity in peroneal nerve sensory showed slowing down than normal before and after the treatment, which were respectively 61% and 32%; The ratios of the nerve conductive velocity in tibial nerve sensory nerve segment 1 showed slowing down before and after the treatment,which were respectively 97% and 65%; The nerve conductive velocity of the peroneal sensory nerve after treatment was significantly faster than that before treatment, the nerve conductive ve-locity of the the tibial nerve sensory nerve motion segments in 1 after treatment was significantly faster than that before treatment. Conclusion Epalrestat is one of the effective methods in the treatment of diabetic peripheral neuropathy.