CAJ | 학술논문

目的：研究FTO基因多态性与肥胖儿童代谢组分相关性。方法选择年龄6~17岁间的599名儿童，检测FTO基因常见的单核苷酸多态性(rs1421085、rs17817449、rs8050136、rs3751812和rs9939609)基因型，分析与肥胖代谢组分的关联性。结果①肥胖儿童代谢组分与对照组有显著差异；②FTO SNPs的等位基因频率与基因型分布存在显著差异。5个FTO SNP突变型是儿童发生肥胖的危险因素；③多变量、Logistic 回归分析发现5个FTO单核苷酸多态性均与高收缩压有关。 rs3751812、rs8050136与 LDL-C、HOMA-IR相关。结论 FTO基因SNPs与儿童肥胖和高血压有关。 rs3751812和 rs8050136与胰岛素抵抗及血清LDL水平升高有关。
목적：연구FTO기인다태성여비반인동대사조분상관성。방법선택년령6~17세간적599명인동，검측FTO기인상견적단핵감산다태성(rs1421085、rs17817449、rs8050136、rs3751812화rs9939609)기인형，분석여비반대사조분적관련성。결과①비반인동대사조분여대조조유현저차이；②FTO SNPs적등위기인빈솔여기인형분포존재현저차이。5개FTO SNP돌변형시인동발생비반적위험인소；③다변량、Logistic 회귀분석발현5개FTO단핵감산다태성균여고수축압유관。 rs3751812、rs8050136여 LDL-C、HOMA-IR상관。결론 FTO기인SNPs여인동비반화고혈압유관。 rs3751812화 rs8050136여이도소저항급혈청LDL수평승고유관。
Objective To investigate whether FTO gene SNP polymorphisms were associated with metabolic traits in Chinese children. Methods A total of 595 children aged between 6 and 17 years were enrolled. The five common SNPs in the FTO gene(rs1421085,rs17817449,rs8050136,rs3751812 and rs9939609)were genotyped. Metabolic compo-nents and insulin were measured. Results (1)The obese patients showed the components of the metabolic traits were significant difference compared to control group.(2)The allele frequency and the genotype distribution of the five SNPs were significant differences between two groups. Minor allele carriers of the five SNPs were associated with increased risks of childhood obesity compared with the wild-type genotype. (3)After adjustment of age, sex and BMI-z score,all of the five SNPs showed a trend towards higher SBP. In addition, rs3751812 and rs8050136 showed significant as-sociation with LDL-C and HOMA-IR levels. Conclusion The five common SNPs in the FTO gene contributes to the e-tiology of obesity and hypertension. The FTO gene polymorphisms (rs3751812 and rs8050136)are found to be associ-ated with increased insulin resistance and plasma LDL levels.