CAJ | 학술논문

目的：探讨常规剂量化疗后Ⅳ度骨髓抑制的治疗。方法：回顾分析笔者所在医院肿瘤内科74例常规剂量化疗后发生Ⅳ度骨髓抑制的治疗。结果：粒细胞减少者，经紫外线病房消毒、G-CSF、抗生素治疗，1/3伴有发热，6例死于肺部感染。血小板减少者，预防性输注血小板，初期57.1%患者有出血现象，均为非致命性，4例3周后血小板低下出血致死，估计与血小板抗体产生有关。结论：粒细胞减少者，积极空气消毒，隔离，抗生素及G-CSF的应用有望改善预后。血小板减少者预防性输注血小板的时机有待进一步研究。
목적：탐토상규제양화료후Ⅳ도골수억제적치료。방법：회고분석필자소재의원종류내과74례상규제양화료후발생Ⅳ도골수억제적치료。결과：립세포감소자，경자외선병방소독、G-CSF、항생소치료，1/3반유발열，6례사우폐부감염。혈소판감소자，예방성수주혈소판，초기57.1%환자유출혈현상，균위비치명성，4례3주후혈소판저하출혈치사，고계여혈소판항체산생유관。결론：립세포감소자，적겁공기소독，격리，항생소급G-CSF적응용유망개선예후。혈소판감소자예방성수주혈소판적시궤유대진일보연구。
Objective:To investigate the treatment of grade Ⅳ bone marrow suppression after conventional chemotherapy.Method:74 cases were analysed the treatment for grade Ⅳ bone marrow suppression after conventional chemotherapy.Result:One per third cases got fever and six cases died of pulmonary infection after treatments of ward ultraviolet disinfection,administration of G-CSF and antibiotics.Those patients with thrombocytopenia were preventively platelet transfusions.At first,57.1% of patients had no lethal hemorrhage.Three weeks later,four cases died of thrombocytopenia inducing hemorrhage,which might be related with the production of platelet antibody.Conclusion:Air disinfection,insulation and these of antibiotics and G-CSF are promising treatments to improve the prognosis of patients with neutropenia.Further research is need to determine the time of preventive platelet transfusions to patients with thrombocytopenia.