CAJ | 학술논문

目的：通过动态血糖检测（ CGMS）比较瑞格列奈和阿卡波糖治疗老年2型糖尿病的疗效。方法选择2O12年1月-2O14年3月本院收治的8O例老年2型糖尿病患者（年龄在6O岁以上）为研究对象，随机分为观察1组和观察2组，各4O例，两组患者均给予饮食和运动疗法，观察1组患者给予瑞格列奈治疗，观察2组患者给予阿卡波糖治疗，持续治疗4周，比较两组患者治疗前后CGMS检测数据，包括空腹血糖、餐后2h血糖、肝功能指标等。结果观察1组治疗后空腹血糖、餐后2h血糖以及肝功能指标低于观察2组，差异有统计学意义（ P<O. O5）；观察1组不良反应发生率低于观察2组，差异有统计学意义（ P<O. O5）。结论瑞格列奈对老年2型糖尿病患者的降糖作用明显优于阿卡波糖，且24h血糖波动幅度较小。
목적：통과동태혈당검측（ CGMS）비교서격렬내화아잡파당치료노년2형당뇨병적료효。방법선택2O12년1월-2O14년3월본원수치적8O례노년2형당뇨병환자（년령재6O세이상）위연구대상，수궤분위관찰1조화관찰2조，각4O례，량조환자균급여음식화운동요법，관찰1조환자급여서격렬내치료，관찰2조환자급여아잡파당치료，지속치료4주，비교량조환자치료전후CGMS검측수거，포괄공복혈당、찬후2h혈당、간공능지표등。결과관찰1조치료후공복혈당、찬후2h혈당이급간공능지표저우관찰2조，차이유통계학의의（ P<O. O5）；관찰1조불량반응발생솔저우관찰2조，차이유통계학의의（ P<O. O5）。결론서격렬내대노년2형당뇨병환자적강당작용명현우우아잡파당，차24h혈당파동폭도교소。
Objective To compare the clinical effect between repaglinide and acarbose in the treatment of elderly pa-tients with type 2 diabetes,evaluated by continuous glucose monitoring system( CGMS). Methods A tota of 8O elderly pa-tients with type 2 diabetes in our hospital from January 2O12 to March 2O14 were randomly divided into the observation group 1 and observation group 2,4O cases in each. Both groups were treated with diet and exercise therapy. The observation group 1 was treated with repaglinide,while observation group 2 was treated with acarbose,the treatment lasted for 4 weeks. The CGMS test data,including fasting blood glucose,postprandial 2h blood glucose,liver function index of two groups were compared. Results After treatment,fasting blood glucose,postprandial 2h plasma glucose and liver function index of observation group 1 were lower than those of observation group 2,the differences were statistically significant(P<O. O5). Incidence of adverse re-actions of observation group 1 was lower than that of observation group 2,the difference was statistically significant(P<O. O5). Conclusion Repaglinide has better clinical effect in the treatment of elderly patients with type 2 diabetes than acarbose,and 24h blood sugar fluctuations is less.