CAJ | 학술논문

目的：研究Galectin-3和CyclinD1在胃癌中表达的相关性及其临床意义。方法收集72例胃癌患者的切除标本作为研究对象。采用免疫组化检测标本的Galectin-3和CyclinD1表达，并探讨与胃癌的病理类型、TNM分期、淋巴结转移、3年无病生存时间的相关性。结果 Galectin-3和CyclinD1在胃癌组织的表达分别为48例（66.7%），42例（58.3%），明显高于癌旁正常组织（P<0.05）。晚期和有淋巴结转移的胃癌Galectin-3和CyclinD1表达显著高于中早期和淋巴结未转移者（P<0.05），Galectin-3和CyclinD1共同表达者3年生存率显著低于阴性者。结论 Galectin-3和CyclinD1是胃癌生物学行为的重要指标，联合检测Galectin-3和CyclinD1对于判定胃癌预后具有重要意义。
목적：연구Galectin-3화CyclinD1재위암중표체적상관성급기림상의의。방법수집72례위암환자적절제표본작위연구대상。채용면역조화검측표본적Galectin-3화CyclinD1표체，병탐토여위암적병리류형、TNM분기、림파결전이、3년무병생존시간적상관성。결과 Galectin-3화CyclinD1재위암조직적표체분별위48례（66.7%），42례（58.3%），명현고우암방정상조직（P<0.05）。만기화유림파결전이적위암Galectin-3화CyclinD1표체현저고우중조기화림파결미전이자（P<0.05），Galectin-3화CyclinD1공동표체자3년생존솔현저저우음성자。결론 Galectin-3화CyclinD1시위암생물학행위적중요지표，연합검측Galectin-3화CyclinD1대우판정위암예후구유중요의의。
Objective To investigate the correlations of the expression of Galectin-3 and CyclinD1 with gastric cancer. Methods The expression of Galectin-3 and CyclinD1 in gastric samples of 72 gastric cancer patients underwent gastric surgery were detected by immunohistochemistry. Results The Galectin-3 and CyclinD1 expression in gastric cancer were 48(66.7%)、42(58.3%),Galectin-3 and Cy-clinD1 expression in the advanced and lymph node metastasis were significantly higher than in the early and without lymph node metastasis(P<0.05). Patients with both Galectin-3 and CyclinD1 expres-sion had much lower survival rate. Conclusion Detection of Galectin-3 and CyclinD1 expression are of great significance for clinicopathological features of gastric cancer. Both Galectin-3 and CyclinD1 can predict prognosis of gastric cancer.