CAJ | 학술논문

高危型人乳头瘤病毒（HPV）基因组整合在宫颈癌等多种肿瘤中被发现。流行病学和实验证据支持高危型HPV基因组整合在宫颈癌等相关肿瘤中起重要作用，其发生可能与宿主染色体不稳定和DNA甲基化相关。近年来发现克隆选择与干扰素通路相关。另外，整合对宿主细胞基因影响和整合位点检测方法方面的研究也取得了重要进展。本文就高危型HPV基因组整合研究的最新进展作一综述。
고위형인유두류병독（HPV）기인조정합재궁경암등다충종류중피발현。류행병학화실험증거지지고위형HPV기인조정합재궁경암등상관종류중기중요작용，기발생가능여숙주염색체불은정화DNA갑기화상관。근년래발현극륭선택여간우소통로상관。령외，정합대숙주세포기인영향화정합위점검측방법방면적연구야취득료중요진전。본문취고위형HPV기인조정합연구적최신진전작일종술。
High-risk human papillomavirus ( HPV ) could integrate into host cell genome in cervical carcinoma .Epidemiological and experimental data support that viral integration plays an important role in cervical carcinogenesis by causing chromosome instability and (or ) DNA methylation . Current studies indicate that interferon pathway may be involved in clone selection .The recent researches on high-risk HPV integration are reviewed .