CAJ | 학술논문

目的：探讨血清白介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）在白癜风患者发病中的作用。方法36例白癜风患者为患者组，皮损分布局限型24例，其中进展期13例，稳定期11例；泛发型12例，其中进展期4例，稳定期8例。20例正常健康者为对照组，两组每人采静脉血3 mL，采用双抗体夹心 ELISA法检测TNF-α、IL-6含量。结果白癜风患者血清TNF-α水平高于正常对照组（P＜0.05）；其中局限型及泛发型白癜风患者血清TNF-α水平均高于正常对照组（P＜0.05）；局限型白癜风患者中进展期与稳定期患者 TNF-α水平差异无统计学意义（P＞0.05）；泛发型白癜风患者中进展期与稳定期患者 TNF-α水平差异有统计学意义（P＜0.01）。白癜风患者血清 IL-6水平高于正常对照组（P＜0.05）；其中局限型及泛发型白癜风患者血清 IL-6水平均高于正常对照组（P＜0.05及P＜0.01）；局限型白癜风患者中进展期与稳定期患者 IL-6水平差异有统计学意义（P＜0.05）；泛发型白癜风患者中进展期与稳定期患者 TNF-α水平差异有统计学意义（P＜0.05）。结论 IL-6和TNF-α可能在白癜风发病中发挥一定作用。
목적：탐토혈청백개소-6（IL-6）화종류배사인자-α（TNF-α）재백전풍환자발병중적작용。방법36례백전풍환자위환자조，피손분포국한형24례，기중진전기13례，은정기11례；범발형12례，기중진전기4례，은정기8례。20례정상건강자위대조조，량조매인채정맥혈3 mL，채용쌍항체협심 ELISA법검측TNF-α、IL-6함량。결과백전풍환자혈청TNF-α수평고우정상대조조（P＜0.05）；기중국한형급범발형백전풍환자혈청TNF-α수평균고우정상대조조（P＜0.05）；국한형백전풍환자중진전기여은정기환자 TNF-α수평차이무통계학의의（P＞0.05）；범발형백전풍환자중진전기여은정기환자 TNF-α수평차이유통계학의의（P＜0.01）。백전풍환자혈청 IL-6수평고우정상대조조（P＜0.05）；기중국한형급범발형백전풍환자혈청 IL-6수평균고우정상대조조（P＜0.05급P＜0.01）；국한형백전풍환자중진전기여은정기환자 IL-6수평차이유통계학의의（P＜0.05）；범발형백전풍환자중진전기여은정기환자 TNF-α수평차이유통계학의의（P＜0.05）。결론 IL-6화TNF-α가능재백전풍발병중발휘일정작용。
Objective To investigate the serum levels of interleukin-6 (IL-6)and tumor necrosis fac-tor-alpha (TNF-α) in the pathogenesis of vitiligo patients. Methods Among 3 6 cases with vitiligo le-sions,limited distribution type was 24 cases,including 13 cases of advanced stage,11 cases of stable stage;12 cases were Pan hair type,including 4 cases of advanced stage,8 cases of stable stage.Mean-while 20 healthy cases were taken as controls.3 mL blood was taken from each case of two groups,and TNF-α,IL-6 were detected by double antibody sandwich ELISA method.Results Serum TNF-αlevel of Vitiligo patients was higher than that of normal control group (P<0.05);Wherein localized and general-ized vitiligo patients serum TNF-αlevels were higher than that of normal control group (P<0.05 );Difference of the TNF-αlevel had no statistical significance in patients with vitiligo confined in progress and stability (P>0.05);Difference in TNF-αwas statistically significant in patients with generalized viti-ligo in progress and stability (P<0.01).Serum IL-6 level in patients with vitiligo was higher than that of normal control group (P<0.05);The level of IL-6 in serum of patients with localized and generalized vit-iligo was higher than that of normal control group (P<0.05 and P<0.01),there were significant differ-ences;The difference of IL-6 between localized patients with vitiligo in progress and stability has statisti-cal significance (P<0.05);The difference in TNF-αlevels was statistically significant in patients with generalized vitiligo in progress and stability (P<0.05).Conclusion Serum levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)might play a role in the pathogenesis of vitiligo.