中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
3期
466-466,468
,共2页
多烯磷脂酰胆碱%辅助化疗%药物性肝损害
多烯燐脂酰膽堿%輔助化療%藥物性肝損害
다희린지선담감%보조화료%약물성간손해
Polyene phosphatidyl choline%Adjuvant chemotherapy%Drug-induced liver damage
目的：观察多烯磷脂酰胆碱在预防乳腺癌术后辅助化疗的护肝作用。方法：将乳腺癌术后首次化疗患者62例随机分为2组，治疗组32例化疗首日开始每日给予多烯磷脂酰胆碱护肝，对照组30例单用化疗。观察比较化疗前后两组肝功能指标的变化。结果：化疗前两组ALT、TBIL比较无显著差异(P>0.05)，化疗后治疗组ALT、TBIL均低于对照组(P<0.01、P<0.05)。结论：多烯磷脂酰胆碱能显著减轻乳腺癌术后化疗引起的药物性肝损害。
目的：觀察多烯燐脂酰膽堿在預防乳腺癌術後輔助化療的護肝作用。方法：將乳腺癌術後首次化療患者62例隨機分為2組，治療組32例化療首日開始每日給予多烯燐脂酰膽堿護肝，對照組30例單用化療。觀察比較化療前後兩組肝功能指標的變化。結果：化療前兩組ALT、TBIL比較無顯著差異(P>0.05)，化療後治療組ALT、TBIL均低于對照組(P<0.01、P<0.05)。結論：多烯燐脂酰膽堿能顯著減輕乳腺癌術後化療引起的藥物性肝損害。
목적：관찰다희린지선담감재예방유선암술후보조화료적호간작용。방법：장유선암술후수차화료환자62례수궤분위2조，치료조32례화료수일개시매일급여다희린지선담감호간，대조조30례단용화료。관찰비교화료전후량조간공능지표적변화。결과：화료전량조ALT、TBIL비교무현저차이(P>0.05)，화료후치료조ALT、TBIL균저우대조조(P<0.01、P<0.05)。결론：다희린지선담감능현저감경유선암술후화료인기적약물성간손해。
Objective: Observe polyene phosphatidyl choline in preventing breast cancer postoperative adjuvant chemotherapy effect that protect liver. Methods:Postoperative breast cancer chemotherapy patients 62 cases were randomly divided into 2 groups for the first time in treatment group and 32 cases of chemotherapy on the first day began to give daily polyene phosphatidyl choline, protect liver, the control group of 30 cases of chemotherapy alone. Compare two sets of changes in liver function indicators before and after chemotherapy. Results: Before chemotherapy compare of ALT, TBIL, two groups had no significant difference(P>0.05), treatment group after chemotherapy ALT, TBIL were lower than control group(P<0.01, P<0.05). Conclusion: Polyene phosphatidyl choline can significantly relieve postoperative drug-induced liver damage caused by chemotherapy of breast cancer.
