CAJ | 학술논문

目的：观察FOLFOX6方案与FOLFIRI方案交替治疗晚期结肠癌的临床疗效。方法：98例晚期结肠癌患者进行FOLFOX6方案与FOLFIRI方案交替治疗,第1疗程按FOLFOX6方案给药；第2疗程按FOLFIRI方案给药；2个方案14天重复1次,2次为1疗程,每2疗程复查,评价疗效。化疗4~6疗程,出现进展停止使用。结果：总有效率为60.2%,对98例患者进行了随访。TTP为9.8个月,1年生存期达80例(81.6%)。毒副反应主要是恶心、呕吐,骨髓抑制,末梢神经炎、迟发性腹泻,乙酰胆碱综合征,脱发等。结论：晚期结肠癌应用FOLFOX6与FOLFIRI交替方案治疗,减少了患者发生耐药性的机会和毒副反应。
목적：관찰FOLFOX6방안여FOLFIRI방안교체치료만기결장암적림상료효。방법：98례만기결장암환자진행FOLFOX6방안여FOLFIRI방안교체치료,제1료정안FOLFOX6방안급약；제2료정안FOLFIRI방안급약；2개방안14천중복1차,2차위1료정,매2료정복사,평개료효。화료4~6료정,출현진전정지사용。결과：총유효솔위60.2%,대98례환자진행료수방。TTP위9.8개월,1년생존기체80례(81.6%)。독부반응주요시악심、구토,골수억제,말소신경염、지발성복사,을선담감종합정,탈발등。결론：만기결장암응용FOLFOX6여FOLFIRI교체방안치료,감소료환자발생내약성적궤회화독부반응。
Objective:To observe clinical efficacy and untoward effect of alternation using of FOLFOX6 and FOLFIRI. Methods:Alternation using of FOLFOX6 and FOLFIRI in 98 patients with advance colon cancer. The first thermotherapy treatment was FOLFOX6;the second thermotherapy treatment was FOLFIRI;14-day cycle, two times was one course;alternated use of the two chemotherapies, clinical efficacy were assessed after each 2 chemotherapies by rechecking, the patients received 4~6 thermotherapy treatment when effective, stopped treatment when progression of disease.Results:Overall response rate was 60.2%,98 patients were followed, time to progression(TTP) was 9.8 months, 80 patients survived one year (81.6%) , Toxic actions and side effects were mainly nausea, vomiting, myelosuppression, nerve endings neuropathy, delayed diarrhea, acetylcholine syndrome, hair loss and ect. Conclusion:Alternation using of FOLFOX6 and FOLFIRI reduced the resistance in patients with advance colon cancer, reduced the accumulative peripheral neurotoxicity and adverse reaction.