CAJ | 학술논문

目的：探讨目标性救治措施救治重症手足口病（ HFMD）患儿的临床效果。方法对2012年在该院住院的138例重症手足口病患儿（研究组）采用目标性救治。同时将该院2010年未进行目标性救治（均按国家诊疗规范救治）的152例患儿作为对照组进行回顾性对比分析。结果研究组的病情加重率低于对照组（P＜0.01），但两组的抢救成功率和病死率比较差异无统计学意义（P均＞0.05）；研究组的症状消失时间和住院时间均短于对照组（ P＜0.05或＜0.01）；研究组的高血糖和神经系统后遗症发生率均低于对照组（ P均＜0.01）。结论目标性救治措施为重症HFMD的救治提供了系统性、可操作性的救治方案，可显著缩短临床症状消失时间和住院时间，降低高血糖和神经系统后遗症的发生率，改善预后。
목적：탐토목표성구치조시구치중증수족구병（ HFMD）환인적림상효과。방법대2012년재해원주원적138례중증수족구병환인（연구조）채용목표성구치。동시장해원2010년미진행목표성구치（균안국가진료규범구치）적152례환인작위대조조진행회고성대비분석。결과연구조적병정가중솔저우대조조（P＜0.01），단량조적창구성공솔화병사솔비교차이무통계학의의（P균＞0.05）；연구조적증상소실시간화주원시간균단우대조조（ P＜0.05혹＜0.01）；연구조적고혈당화신경계통후유증발생솔균저우대조조（ P균＜0.01）。결론목표성구치조시위중증HFMD적구치제공료계통성、가조작성적구치방안，가현저축단림상증상소실시간화주원시간，강저고혈당화신경계통후유증적발생솔，개선예후。
Objective To explore the clinical efficacy of targeted treatment measures for children with severe hand-foot-mouth disease ( HFMD ) .Methods On the basis of the mational standard for diagnosis and treatment of HFMD in the treatment group , 138 children with severe HFMD hospitalized in our hospital in 2012 were treated by targeted treatment measures;in the control group 152 children with severe HFMD were not treated by targeted treat-ment measures , and the clinical efficacy between two groups were retrospectively compared .Results The disease ex-acerbation rate in the treatment group was lower than that in the control group ( P<0.01 ) , but the rescue success rate and case fatality rate were similar between the two groups ( P>0.05 );the symptems disappearing time and length of hospital stay and breathing machine utilization rate in the treatment group were shorter than those in the control group ( P<0.05 or <0.01 );the incidence of complications and sequela in the treatment group were lower than those in the control group ( P<0.01 ) .Conclusion Targted treatment measares provide a systematic and operational scheme for treating severe HFMD ,can obviously shorten the clisappearing time of clinical symptoms and hospitalizationg time , reduce the incidence of hyperglycemia and the sequela of the nerves system ,and improve the prognosis .