CAJ | 학술논문

目的：探讨慢性丙型肝炎患者自身抗体的阳性率及临床意义。方法：应用ELISA法检测105例慢性丙型肝炎患者血清中的抗核抗体，用免疫印迹法检测抗肝肾微粒体抗体，选择96例慢性乙型肝炎患者和80例健康人分别作为对照组。结果：105例慢性丙型肝炎患者自身抗体总阳性率为48.6%，显著高于慢性乙肝组(7.3%)和健康对照组(2.5%)。自身抗体阳性组患者的平均年龄(47.3±15.5)大于自身抗体阴性组(38.1±14.9)(P<0.05)。自身抗体阳性组中肝纤维化发生率(68.6%)高于自身抗体阴性组(48.1%)(P<0.05)。但两组间性别构成和HCV RNA阳性率无显著性差异(P>0.05)。结论：血清自身抗体的检测有助于慢性丙型肝炎的诊治和病情评估。
목적：탐토만성병형간염환자자신항체적양성솔급림상의의。방법：응용ELISA법검측105례만성병형간염환자혈청중적항핵항체，용면역인적법검측항간신미립체항체，선택96례만성을형간염환자화80례건강인분별작위대조조。결과：105례만성병형간염환자자신항체총양성솔위48.6%，현저고우만성을간조(7.3%)화건강대조조(2.5%)。자신항체양성조환자적평균년령(47.3±15.5)대우자신항체음성조(38.1±14.9)(P<0.05)。자신항체양성조중간섬유화발생솔(68.6%)고우자신항체음성조(48.1%)(P<0.05)。단량조간성별구성화HCV RNA양성솔무현저성차이(P>0.05)。결론：혈청자신항체적검측유조우만성병형간염적진치화병정평고。
Objective:To investigate the positive rate and clinical significance of autoantibodies in patients with chronic hepatitis C. Methods:Anti-nuclear antibodies were detected by ELISA for 105 patients. Anti-LKM-1 were detected by Western blotting. 96 cases of patients with chronic hepatitis B and 80 healthy subjects were respectively selected for control group. Results:In chronic hepatitis C group, the total positive rate of autoantibodies was 48.6%(51/105), which was higher than chronic hepatitis B(7.3%) or healthy group(2.5%) (P<0.05). In autoantibody positive group, the age was higer than that in autoantibody negative group[(47.3±15.5) vs (38.1±14.9),P<0.05] as well as the cirrhosis prevalence rate(62.7%vs 48.1%,P<0.05). There was no significance difference in both gender composition and HCV RNA positive rate in the above groups(P>0.05). Conclusion:Detection of serum autoantibodies are useful for diagnosis, therapy and severity evaluation in chronic hepatitis C.