CAJ | 학술논문

目的：探讨川穹嗪对于Aβ1-42致痴呆模型小鼠学习记忆功能的影响，并对其机制进行初步研究。方法：通过避暗实验、跳台实验检测小鼠学习记忆功能；通过胞内钙影像测定胞内钙浓度变化。结果：避暗实验和跳台实验均表明，高中低剂量组的川穹嗪与模型组相比，能显著增加潜伏期，减少错误次数(P<0.05)；胞内钙影像结果表明，在有钙或无钙外液两种情况下，川穹嗪均降低海马神经元胞内钙离子浓度。结论：川穹嗪可显著改善Aβ1-42致痴呆模型小鼠学习记忆功能，其机制可能与川穹嗪降低胞内钙离子浓度，从而调节神经元兴奋性，突触可塑性和信号传递有关。
목적：탐토천궁진대우Aβ1-42치치태모형소서학습기억공능적영향，병대기궤제진행초보연구。방법：통과피암실험、도태실험검측소서학습기억공능；통과포내개영상측정포내개농도변화。결과：피암실험화도태실험균표명，고중저제량조적천궁진여모형조상비，능현저증가잠복기，감소착오차수(P<0.05)；포내개영상결과표명，재유개혹무개외액량충정황하，천궁진균강저해마신경원포내개리자농도。결론：천궁진가현저개선Aβ1-42치치태모형소서학습기억공능，기궤제가능여천궁진강저포내개리자농도，종이조절신경원흥강성，돌촉가소성화신호전체유관。
Objectives:To discuss tetramethylpyrazine (TMP)’s influence on learning and memorial function of Aβ1-42 caused AD model mouse and its potential mechanism. Methods:Tested mouse’s learning and memorial function through step-through test and step-down test;Measured calcium concentration through intracellular calcium imaging. Results:Behavior test showed that compared to model group, TMP can increase the latent period and reduce error times significantly(P<0.05);calcium image results showed that TMP can reduce calcium concentration of hippocampal neurons in the extracellular solution with calcium or without calcium. Conclusion:TMP can improve learning and memorial functions of Aβ1-42 caused AD mouse significantly. The mechanism may due to TMP can reduce intracellular calcium ion concentration, therefore regulate neuronal excitability, neuronal plasticity and signal transmission.