CAJ | 학술논문

目的：寻找重症监护病房深部真菌感染患者在治疗期间疗效监测的另外一种新的评估手段方法搜集深圳市福田区人民医院2011-2013年重症监护病房临床诊断、拟诊侵袭性肺部真菌感染合并1,3-β-D葡聚糖升高患者30例，在治疗前、治疗后3天、7天、14天、21天进行血清1,3-β-D葡聚糖检测，进行调查分析。结果30例患者死亡3例，全部患者在抗真菌治疗前1,3-β-D葡聚糖平均值为36.37pg/ml，在抗真菌治疗开始后2例患者1,3-β-D葡聚糖无明显下降，其余25例均呈明显下降，并在1,3-β-D葡聚糖降至一定水平时停药，结果无1例病情反复。结论1,3-β-D葡聚糖可作为深部真菌感染患者抗真菌感染的疗效监测指标。
목적：심조중증감호병방심부진균감염환자재치료기간료효감측적령외일충신적평고수단방법수집심수시복전구인민의원2011-2013년중증감호병방림상진단、의진침습성폐부진균감염합병1,3-β-D포취당승고환자30례，재치료전、치료후3천、7천、14천、21천진행혈청1,3-β-D포취당검측，진행조사분석。결과30례환자사망3례，전부환자재항진균치료전1,3-β-D포취당평균치위36.37pg/ml，재항진균치료개시후2례환자1,3-β-D포취당무명현하강，기여25례균정명현하강，병재1,3-β-D포취당강지일정수평시정약，결과무1례병정반복。결론1,3-β-D포취당가작위심부진균감염환자항진균감염적료효감측지표。
Objective To find a new evaluation method in treatment of ICU patients infected by invasive fungus. Methods 30 cases infected by invasive fungus and accompanied by elevation of (1,3)-β-D Glucan were col ected in ICU of Futian District People’s Hospital from 2011-2013. Serum (1,3)-β-D Glucan were measured on the 0, 3rd, 7th, 14th and 21st day of the treatment, al data were analyzed by statistical software. Results There were three death cases total y. The mean value of serum (1,3)-β-D Glucan before antifungal therapy was 36.37pg/ml, and the mean value appeared significant descending in 25 cases after antifungal therapy started. Antifungal therapy ceased when (1,3)-β-D Glucan level dropped to a certain degree ,and there’s no deterioration case. Conclusion Serum (1,3)-β-D Glucan level can be regarded as an criterion of therapeutic effect in patients infected by invasive fungus.