CAJ | 학술논문

目的：通过纠正体质偏向的方法自拟处方观察非酒精性脂肪性肝炎的临床疗效。方法：筛选出的80例痰瘀体质非酒精性脂肪性肝炎患者分成治疗组40例和对照组40例。两组患者均接受基础治疗（包括合理饮食和适当运动）。治疗组使用益肝解毒方进行药物干预治疗，对照组使用益肝灵治疗，治疗周期为3个月。疗程结束后观察非酒精性脂肪性肝炎患者痰瘀体质积分、肝功能、血脂的变化情况。结果：治疗组治疗后在痰瘀体质积分的改善上与对照组比较具有统计学意义（ P＜0.05）；治疗组治疗后血清ALT、AST、GGT均值与对照组比较具有统计学意义（P＜0.05）。治疗组综合有效率为75.00％，对照组综合有效率为52.25％，两组比较有统计学意义（ P＜0.01）。结论：益肝解毒方能有效改善NASH患者的体质偏向，可降低NASH患者肝酶指标，具有改善NASH患者血脂和体重指数的趋势。
목적：통과규정체질편향적방법자의처방관찰비주정성지방성간염적림상료효。방법：사선출적80례담어체질비주정성지방성간염환자분성치료조40례화대조조40례。량조환자균접수기출치료（포괄합리음식화괄당운동）。치료조사용익간해독방진행약물간예치료，대조조사용익간령치료，치료주기위3개월。료정결속후관찰비주정성지방성간염환자담어체질적분、간공능、혈지적변화정황。결과：치료조치료후재담어체질적분적개선상여대조조비교구유통계학의의（ P＜0.05）；치료조치료후혈청ALT、AST、GGT균치여대조조비교구유통계학의의（P＜0.05）。치료조종합유효솔위75.00％，대조조종합유효솔위52.25％，량조비교유통계학의의（ P＜0.01）。결론：익간해독방능유효개선NASH환자적체질편향，가강저NASH환자간매지표，구유개선NASH환자혈지화체중지수적추세。
Objective:To observe the therapeutic effect of TCM on NASH based on the theory of constitution being adjustable .Methods:Eighty patients with nonalcoholic steatohepatitis of phlegm-blood stasis constitution were screened and divided into control group ( n=40) and treatment group(n=40).Patients in both groups were treated with suitable diet and exercise called as foundation therapy . Treatment group gave patients TCM of Yiganjiedu formula .Control group applied silymarin ( SM ) .The courses of treatment of both groups were 3 months.The changes of constitution scores , hepatic function and blood fat were observed to evaluate .Drugs that potential-ly affect liver function and serum lipid were not allowed to use during the observation period .Results:The results of constitution scores between control group and treatment group had statistically significant differences ( P<0.05 ) .The comparisons of hepatic function be-tween the two groups had statistically significant differences (P<0.05).The total effective rate of treatment group was 75.00%, and that of the control group was 52.25%.The results had statistical significance (P<0.01).Conclusion:The treatment of TCM can sig-nificantly regulate constitution scores and reduce levels of ALT , AST, GGT, and it has the trend of lowering body mass index ( BMI) and blood lipid .