CAJ | 학술논문

目的：探讨芪归银方含药血清联合抗生素对多重耐药铜绿假单胞菌的体外抑制作用。方法：运用二倍稀释法检测单用抗生素、空白血清、含药血清及血清联合抗生素的体外抑菌情况。结果：空白血清对多重耐药铜绿假单胞菌无体外抑菌作用，含药血清则具有明显的体外抑菌作用；抗生素联合含药血清较单纯抗生素和抗生素联合空白血清的抑菌情况有明显差异。结论：芪归银方含药血清能够降低抗生素的MIC值、MBC值，提高抑菌率，含药血清与抗生素具有体外协同抑菌作用。
목적：탐토기귀은방함약혈청연합항생소대다중내약동록가단포균적체외억제작용。방법：운용이배희석법검측단용항생소、공백혈청、함약혈청급혈청연합항생소적체외억균정황。결과：공백혈청대다중내약동록가단포균무체외억균작용，함약혈청칙구유명현적체외억균작용；항생소연합함약혈청교단순항생소화항생소연합공백혈청적억균정황유명현차이。결론：기귀은방함약혈청능구강저항생소적MIC치、MBC치，제고억균솔，함약혈청여항생소구유체외협동억균작용。
Objective:To explore the bacteriostasis effect of Qiguiyin decoction combined with antibiotics inhibiting multi -drug resistant pseudomonas aeruginosa in vitro .Methods:The antibacterial situation of antibiotics , blank serum , Qiguiyin decoction-containing se-rum and Qiguiyin decoction&antibiotics-containing serum in vitro were detected with double dilution method .Results:Blank serum had no effect of bacteriostasis on multi-drug resistant PA , while Qiguiyin decoction-containing serum had significant effect of bacteriostasis on it, and there was significant difference between them .Besides, the serum with both Qiguiyin decoction and antibiotics showed more sig-nificant bacteriostasis effect .Conclusion:Qiguiyin decoction-containing serum could reduce the content of MIC , MBC in antibiotics and increase the bacteriostasis rate .Qiguiyin Decoction-containing serum and antibiotics have significant cooperation effect of bacteriostasis on PA in vitro .