CAJ | 학술논문

[目的]从免疫学和流行病学两个方面评价上海市虹口区6～14岁学龄儿童麻疹疫苗强化免疫的效果。[方法]强化免疫1个月后采集静脉血，采用ELISA法测定麻疹IgG抗体，与未参加强化免疫者的抗体水平进行比较。同时，收集研究个体的麻疹免疫史、麻疹病史、麻疹密切接触史等流行病学资料。[结果]不能认为强化免疫对提高虹口区6～14岁学龄儿童麻疹抗体的阳性率、保护率及几何抗体平均浓度有影响，麻疹疫苗接种2剂次与接种3～4剂次相比，抗体水平差异无统计学意义。[结论]强化免疫的目的是消除免疫空白，在常规免疫高接种率的地区，实施大规模的强化免疫是对疫苗资源、人力资源和财力资源的浪费，而查漏补种是经济有效的预防措施。
[목적]종면역학화류행병학량개방면평개상해시홍구구6～14세학령인동마진역묘강화면역적효과。[방법]강화면역1개월후채집정맥혈，채용ELISA법측정마진IgG항체，여미삼가강화면역자적항체수평진행비교。동시，수집연구개체적마진면역사、마진병사、마진밀절접촉사등류행병학자료。[결과]불능인위강화면역대제고홍구구6～14세학령인동마진항체적양성솔、보호솔급궤하항체평균농도유영향，마진역묘접충2제차여접충3～4제차상비，항체수평차이무통계학의의。[결론]강화면역적목적시소제면역공백，재상규면역고접충솔적지구，실시대규모적강화면역시대역묘자원、인력자원화재력자원적낭비，이사루보충시경제유효적예방조시。
Objective] To analyze the effect of enhanced immunization for school-age children in Hongkou District of Shanghai in immunology and epidemiology . [ Methods] One month after completing immunization, the blood antibody titers were measured by ELISA method , and compared with the those of non-enhanced immunization , for epidemiological survey were collected history of measles immunization and close contact with the measles . [ Results] It could not be thought that strengthening immunization im-proved antibody positivity rate , the protection rate , and geometric antibody average concentrations .There was not statistical difference in antibody levels between measles vaccination 2 times and 3 -4 times. [ Conclusion] In the regions where routine immunization rates reach a high level , strengthening immuni-zation done on large scale is a waste of vaccine resources , human resources and financial resources , and leak re-vaccination should be done as a cost-effective preventive measure .