CAJ | 학술논문

目的：收集北京大学人民医院疑似非淋球菌尿道炎泌尿生殖道标本130份，分析支原体感染的情况及耐药状况，帮助临床合理选用抗生素，提高疗效。方法对130份标本用支原体培养、鉴定、计数及药敏试验试剂盒（比色法）（Mycoplasma IST2）进行支原体的检测、计数及药敏试验。结果在130份标本中，检出支原体共59份，检出率为45．4％。解脲脲原体（Uu）、人型支原体（Mh）和 Uu 联合 Mh 的阳性率分别为42．3％（55份）、1．5％（2份）和1．4％（2份）。Uu 对抗菌药物的敏感率分别为多西环素（100％）、四环素（98．2％）、交沙霉素（89．1％）、克拉霉素（87．3％）等。耐药率最高的是环丙沙星（73．4％），其次是氧氟沙星（47．3％）。结论在支原体导致的非淋球菌尿道炎中，主要由 Uu 引起（93．2％，55/59）；临床治疗推荐使用多西环素、四环素、交沙霉素、克拉霉素。
목적：수집북경대학인민의원의사비림구균뇨도염비뇨생식도표본130빈，분석지원체감염적정황급내약상황，방조림상합리선용항생소，제고료효。방법대130빈표본용지원체배양、감정、계수급약민시험시제합（비색법）（Mycoplasma IST2）진행지원체적검측、계수급약민시험。결과재130빈표본중，검출지원체공59빈，검출솔위45．4％。해뇨뇨원체（Uu）、인형지원체（Mh）화 Uu 연합 Mh 적양성솔분별위42．3％（55빈）、1．5％（2빈）화1．4％（2빈）。Uu 대항균약물적민감솔분별위다서배소（100％）、사배소（98．2％）、교사매소（89．1％）、극랍매소（87．3％）등。내약솔최고적시배병사성（73．4％），기차시양불사성（47．3％）。결론재지원체도치적비림구균뇨도염중，주요유 Uu 인기（93．2％，55/59）；림상치료추천사용다서배소、사배소、교사매소、극랍매소。
Objective A total of 130 clinical specimens were collected from the patients who were suspected of nongonococcal u-rethritis (NGU)in People′s Hospital of Beijing University.The prevalence and antibiotic susceptibility of mycoplasmal patho-gens were studied to help clinicians manage such infections more reasonably and effectively.Methods Comercial kit (Mycoplas-ma IST2)was used for culture,identification,counting,and susceptibility testing of Mycoplasma strains.Results Mycoplas-ma was identified in 59 (45.4%)of the 130 specimens.Ureaplasma urealyticum (Uu)alone,Mycoplasma hominis (Mh)a-lone and Uu plus Mh mixed infection were found in 55 (42.3%),2 (1.5%),and 2 (1.5%)cases,respectively.Susceptibility testing of 55 Uu strains showed that these strains were highly susceptible to doxycycline (100%),tetracycline (98.2%),josa-mycin (89.1%),and clarithromycin (87.3%).But these strains were mostly resistant to ciprofloxacin (73.4%),followed by ofloxacin (47.3%).Conclusions The nongonococcal urethritis caused by Mycoplasma is predominantly due to Uu (93.2%, 55/59).Doxycycline,tetracycline,josamycin and clarithromycin should be recommended for clinical treatment of such infec-tions.