中国感染与化疗杂志
中國感染與化療雜誌
중국감염여화료잡지
CHINESE JOURNAL OF INFECTION AND CHEMOTHERAPY
2014年
2期
149-152
,共4页
儿童%沙门菌%抗生素%耐药性
兒童%沙門菌%抗生素%耐藥性
인동%사문균%항생소%내약성
children%Salmonella%serotype%antibiotic sensitivity
目的：了解中山市区腹泻儿童中沙门菌感染的流行病学特征及其对抗菌药物敏感性，为临床选用抗菌药物提供依据。方法中山市博爱医院2009年9月至2013年4月儿科门诊及住院腹泻患儿的粪便标本中，共检出沙门菌属344株，检出率为5．0％，采用 VITEK-2 Compact 进行药敏试验。结果344株沙门菌属经血清学鉴定，鼠伤寒沙门菌185株（53．8％），斯坦利沙门菌43株（12．5％），肠炎沙门菌29株（8．4％）。男女比例为1．8∶1；＜1岁的婴儿占68．9％。药敏试验结果显示，沙门菌属对左氧氟沙星、哌拉西林-他唑巴坦、头孢吡肟、头孢他啶、头孢曲松有较高的敏感率，为88．9％～98．0％，对氨苄西林敏感率较低，为39．2％。结论中山市区引起儿童腹泻的沙门菌属感染以鼠伤寒沙门菌为主，其次为斯坦利沙门菌和肠炎沙门菌。夏秋季为高发季节。1岁以下婴儿为易感人群，男性患儿较多。治疗时应根据药敏试验合理、谨慎选用抗生素。
目的：瞭解中山市區腹瀉兒童中沙門菌感染的流行病學特徵及其對抗菌藥物敏感性，為臨床選用抗菌藥物提供依據。方法中山市博愛醫院2009年9月至2013年4月兒科門診及住院腹瀉患兒的糞便標本中，共檢齣沙門菌屬344株，檢齣率為5．0％，採用 VITEK-2 Compact 進行藥敏試驗。結果344株沙門菌屬經血清學鑒定，鼠傷寒沙門菌185株（53．8％），斯坦利沙門菌43株（12．5％），腸炎沙門菌29株（8．4％）。男女比例為1．8∶1；＜1歲的嬰兒佔68．9％。藥敏試驗結果顯示，沙門菌屬對左氧氟沙星、哌拉西林-他唑巴坦、頭孢吡肟、頭孢他啶、頭孢麯鬆有較高的敏感率，為88．9％～98．0％，對氨芐西林敏感率較低，為39．2％。結論中山市區引起兒童腹瀉的沙門菌屬感染以鼠傷寒沙門菌為主，其次為斯坦利沙門菌和腸炎沙門菌。夏鞦季為高髮季節。1歲以下嬰兒為易感人群，男性患兒較多。治療時應根據藥敏試驗閤理、謹慎選用抗生素。
목적：료해중산시구복사인동중사문균감염적류행병학특정급기대항균약물민감성，위림상선용항균약물제공의거。방법중산시박애의원2009년9월지2013년4월인과문진급주원복사환인적분편표본중，공검출사문균속344주，검출솔위5．0％，채용 VITEK-2 Compact 진행약민시험。결과344주사문균속경혈청학감정，서상한사문균185주（53．8％），사탄리사문균43주（12．5％），장염사문균29주（8．4％）。남녀비례위1．8∶1；＜1세적영인점68．9％。약민시험결과현시，사문균속대좌양불사성、고랍서림-타서파탄、두포필우、두포타정、두포곡송유교고적민감솔，위88．9％～98．0％，대안변서림민감솔교저，위39．2％。결론중산시구인기인동복사적사문균속감염이서상한사문균위주，기차위사탄리사문균화장염사문균。하추계위고발계절。1세이하영인위역감인군，남성환인교다。치료시응근거약민시험합리、근신선용항생소。
Objective To investigate the epidemiological characteristics and antibiotic sensitivity of Salmonella infection in children with diarrhea in Zhongshan City for rational use of antibiotics.Methods A total of 6 920 stool specimens were collected from children with diarrhea including outpatients and inpatients in Zhongshan Boai Hospital from September 2009 to April 2013.Salmonella strains (n = 344)were isolated and identified by enrichment culture.The overall infection rate was 5.0%(344/6 920).Antimicrobial susceptibility was tested by VITEK-2 Compact automicroscan.Results Of the 344 strains of Sal-monella,185 (53.8%)strains were Salmonella typhimurium ,43 (12.5%)were Salmonella stanley ,29 (8.4%)were Sal-monella enteritidis .The male-to-female ratio was 1.8∶1 for the children with diarrhea.The infection rate was 68.9% (237/344)in children under 1-year old.Susceptibility testing results indicated that majority (88.9%-98.0%)of these Salmonella strains were susceptible to levofloxacin,piperacillin-tazobactam,cefepime,ceftazidime,and ceftriaxone,but to ampicillin, 39.2% of the strains were susceptible.Conclusions Most Salmonella infections in Zhongshan City were caused by Salmonella typhimurium,followed by Salmonella stanley and Salmonella enteritidis .Such infections usually peak in summer and autumn seasons.The chidren under 1-year old were more susceptible to Salmonella infections.Higher incidence of infection is associat-ed with boys.Antibiotics should be chosen reasonably and prudently based on antimicrobial sensitivity testing.
