CAJ | 학술논문

目的：探讨恶性肿瘤特异性标志物在肺癌早期诊断中的应用。方法选取商丘市第一人民医院2011年7月~2013年7月收治的52例肺癌患者、52例良性病变患者及52例健康体验者作为研究对象,分为肺癌组、良性组、健康组。分别测定三组癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、癌抗原125(CA125)、细胞角蛋白21-1片断(CYFRA21-1)、胃泌素释放肽前体(ProGRP)的含量,评价其在肺癌早期诊断中的价值。结果肺癌组CEA、NSE、CA125、CYFRA21-1、ProGRP的含量分别为(28.6±11.5)μg/L、(44.2±18.4)μg/L、(86.4±23.7) U/ml、(23.5±10.8)μg/L、(69.5±17.4) ng/L,均高于良性组和健康组,差异有统计学意义(P<0.05)。结论单独检测恶性肿瘤特异性标志物对于恶性肿瘤早期诊断具有一定的局限性,联合检测对早期诊断有重要的参考价值。
목적：탐토악성종류특이성표지물재폐암조기진단중적응용。방법선취상구시제일인민의원2011년7월~2013년7월수치적52례폐암환자、52례량성병변환자급52례건강체험자작위연구대상,분위폐암조、량성조、건강조。분별측정삼조암배항원(CEA)、신경원특이성희순화매(NSE)、암항원125(CA125)、세포각단백21-1편단(CYFRA21-1)、위비소석방태전체(ProGRP)적함량,평개기재폐암조기진단중적개치。결과폐암조CEA、NSE、CA125、CYFRA21-1、ProGRP적함량분별위(28.6±11.5)μg/L、(44.2±18.4)μg/L、(86.4±23.7) U/ml、(23.5±10.8)μg/L、(69.5±17.4) ng/L,균고우량성조화건강조,차이유통계학의의(P<0.05)。결론단독검측악성종류특이성표지물대우악성종류조기진단구유일정적국한성,연합검측대조기진단유중요적삼고개치。
Objective To investigate the cancer-specific markers in the early diagnosis of lung cancer. Methods First People's Hospital of Shangqiu City, From July 2011 to July 2013 treated 52 patients with lung cancer, 52 cases and 52 cases of benign lesions in patients who experience health as research subjects, divided into groups of lung cancer, benign group, healthy group . Three groups were measured carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cancer antigen 125 (CA125), 21-1 cytokeratin fragment (CYFRA21-1), gastrin-releasing peptide ( ProGRP) content, evaluate its value in the early diagnosis of lung cancer. Results The lung cancer group CEA, NSE, CA125, CYFRA21-1, ProGRP contents were (28.6±11.5) ug/L, (44.2±18.4)μg/L, (86.4±23.7) U/ml, (23.5±10.8)μg/L, (69.5±17.4) ng/L, were higher than the benign group and healthy group, the difference was statistically significant (P<0.05). Conclusion Separate detection of tumor specific markers for early diagnosis of cancer has certain limitations, combined detection of early diagnosis has important reference value.