CAJ | 학술논문

目的：观察帕瑞昔布钠复合地佐辛预防全身麻醉苏醒期躁动的作用。方法全身麻醉下行择期甲状腺切除术患者120例随机均分为帕瑞昔布钠组（P组）、帕瑞昔布钠＋地佐辛组（PD组）、地佐辛组（D组）和等容生理盐水组（C组）4组（n=30）。P组麻醉诱导前静注帕瑞昔布钠40 mg组、PD组麻醉诱导前静注帕瑞昔布钠40 mg并手术结束前30 min静注地佐辛0.1 mg/kg、D组手术结束前30 min静注地佐辛0.1 mg/kg，C组给予等容生理盐水。观察苏醒期躁动的发生情况。结果与C组比较，P、PD、D组苏醒期躁动发生显著减少（P<0.01），BCS分级和Ramsay评分更高（P<0.01），VAS评分更低（P<0.01）；与P组和D组比较，PD组苏醒期躁动发生显著减少（P<0.05或0.01），BCS分级和Ramsay评分更高（P<0.05或0.01），VAS评分更低（P<0.05或0.01）。结论帕瑞昔布钠40 mg复合地佐辛0.1 mg/kg能更好地预防全身麻醉苏醒期躁动，有效提高苏醒期质量。
목적：관찰파서석포납복합지좌신예방전신마취소성기조동적작용。방법전신마취하행택기갑상선절제술환자120례수궤균분위파서석포납조（P조）、파서석포납＋지좌신조（PD조）、지좌신조（D조）화등용생리염수조（C조）4조（n=30）。P조마취유도전정주파서석포납40 mg조、PD조마취유도전정주파서석포납40 mg병수술결속전30 min정주지좌신0.1 mg/kg、D조수술결속전30 min정주지좌신0.1 mg/kg，C조급여등용생리염수。관찰소성기조동적발생정황。결과여C조비교，P、PD、D조소성기조동발생현저감소（P<0.01），BCS분급화Ramsay평분경고（P<0.01），VAS평분경저（P<0.01）；여P조화D조비교，PD조소성기조동발생현저감소（P<0.05혹0.01），BCS분급화Ramsay평분경고（P<0.05혹0.01），VAS평분경저（P<0.05혹0.01）。결론파서석포납40 mg복합지좌신0.1 mg/kg능경호지예방전신마취소성기조동，유효제고소성기질량。
Objective To observe the effect of parecoxib combined dezocine on preventing agitation during wake-up from general anesthesia. Methods A total of 120 patients undergoing selective thyroidectomy under general anesthesia were randomly divided into 4 groups with 30 cases each. Group P received parecoxib 40 mg iv before induction of anesthesia, group PD received parecoxib 40 mg iv before induction of anesthesia plus dezocine 0.1 mg/kg iv 30 min before the end of operation, group D received dezocine 0.1 mg/kg iv 30 min before the end of operation,group C received equal volume of normal saline. The occurrence of agitation was observed during waking-up period in PACU. Results The rates of agitation was signiifcantly decreased in group s of P,PD and D than that in group of C ,The BCS and Ramsay values were higher and VAS values were lower than that in group of C. Conclusion Parecoxib 40 mg combined 0.1 mg/kg of dezocine can safely and effectively prevent the incidence of emergence agitation, so that to ensure the patients during analqesia period .