CAJ | 학술논문

目的：探讨联合检测血清糖类抗原（CA）15-3、CA125、癌胚抗原（CEA）对乳腺癌的诊断价值。方法对112例乳腺癌患者和49例乳腺良性疾病患者进行血清CA15-3、CA125、CEA联合检测。比较2组患者及乳腺癌组不同临床分期患者3种肿瘤标志物含量和阳性率，并比较3种肿瘤标志物联合与单项检测对乳腺癌的诊断效能。结果乳腺癌组血清CA15-3、CA125及CEA水平和阳性率高于乳腺良性疾病组（P＜0．05）；乳腺癌Ⅲ～Ⅳ期患者血清CA15-3、CA125及CEA水平和阳性率高于Ⅰ～Ⅱ期患者（P＜0．05）；乳腺癌患者肿瘤标志物联合检测阳性率高于任何一种单项检测；联合检测提高了Ⅰ～Ⅱ期和Ⅲ～Ⅳ期患者的阳性率，Ⅰ～Ⅱ期患者提高幅度较大；3种肿瘤标志物联合检测提高了乳腺癌患者单项检测的敏感性、准确度和阴性预测值，但特异性和阳性预测值稍降低。结论 CA15-3、CA125、CEA联合检测可弥补单项检测的不足，对于肿瘤的早期诊断、临床分期具有重要意义。
목적：탐토연합검측혈청당류항원（CA）15-3、CA125、암배항원（CEA）대유선암적진단개치。방법대112례유선암환자화49례유선량성질병환자진행혈청CA15-3、CA125、CEA연합검측。비교2조환자급유선암조불동림상분기환자3충종류표지물함량화양성솔，병비교3충종류표지물연합여단항검측대유선암적진단효능。결과유선암조혈청CA15-3、CA125급CEA수평화양성솔고우유선량성질병조（P＜0．05）；유선암Ⅲ～Ⅳ기환자혈청CA15-3、CA125급CEA수평화양성솔고우Ⅰ～Ⅱ기환자（P＜0．05）；유선암환자종류표지물연합검측양성솔고우임하일충단항검측；연합검측제고료Ⅰ～Ⅱ기화Ⅲ～Ⅳ기환자적양성솔，Ⅰ～Ⅱ기환자제고폭도교대；3충종류표지물연합검측제고료유선암환자단항검측적민감성、준학도화음성예측치，단특이성화양성예측치초강저。결론 CA15-3、CA125、CEA연합검측가미보단항검측적불족，대우종류적조기진단、림상분기구유중요의의。
Objective To investigate the clinical value of combined detection of serum carbohydrate antigen ( CA) 15-3,CA125,carcinoembryonic antigen ( CEA) in the diagnosis of breast cancer .Methods Serum CA15-3,CEA,and CA125 were detected in 112 patients with breast cancer and 49 patients with benign breast disease .Content and positive rates of the 3 tumor markers in the 2 groups and different stages of the breast cancer group were compared ,and value of combined detection of the 3 tumor markers and detection of single tumor marker in the diagnosis of breast cancer were compared .Results Serum level and positive rates of CA15-3,CA125 and CEA in the breast cancer group were higher than those of the breast benign disease group ( P<0.05);serum level and positive rates of CA 15-3,CA125 and CEA of stage Ⅲ~Ⅳbreast cancer were higher than those of the stageⅠ~Ⅱbreast cancer (P<0.05);combined detection of the 3 tumor markers had higher positive rates in breast cancer pa-tients than that of any single detection;Combined detection improved the positive rates of stageⅠ~Ⅱ and stage Ⅲ~Ⅳ breast cancer patients ,stageⅠ~Ⅱpatients had significant increased;combined detection of the 3 tumor markers in patients with breast cancer improved individual sensitivity ,accuracy and negative predictive value ,while reduced the specificity and positive predictive value slightly.Conclusion Combined detection of CA15-3,CA125,CEA can make up for the shortage of single detection ,and it is important for early diagnosis and clinical staging .