CAJ | 학술논문

目的：观测白藜芦醇对年龄相关自发性高血压大鼠动脉舒张功能的改善效果及年龄对动脉功能与疗效的影响。方法：雄性年轻期（8～10周龄）、中老年期（9～10月龄）的自发性高血压大鼠及健康对照大鼠，其中高血压大鼠随机分为白藜芦醇干预组和非干预组，干预组给予白藜芦醇10mg/（kg·d）灌胃，记录大鼠血压、心率，检测胸主动脉与肠系膜动脉对乙酰胆碱的舒张特性，检测肠系膜动脉中总一氧化氮（NO）及gp91phox 的表达。结果：（1）与年轻期高血压大鼠相比，中老年高血压大鼠的动脉舒张功能减弱，白藜芦醇治疗后舒张功能增强。（2）白藜芦醇治疗能够增加年轻与中老年高血压大鼠的肠系膜动脉总 NO 量，减少 gp91phox 蛋白表达。结论：高血压大鼠动脉内皮依赖的舒张功能较正常大鼠减弱且存在年龄差异，摄入白藜芦醇可以通过减少gp91phox 表达，增加 NO 量来保护血管舒张功能，该保护作用在年轻期与中老年期大鼠中均存在。
목적：관측백려호순대년령상관자발성고혈압대서동맥서장공능적개선효과급년령대동맥공능여료효적영향。방법：웅성년경기（8～10주령）、중노년기（9～10월령）적자발성고혈압대서급건강대조대서，기중고혈압대서수궤분위백려호순간예조화비간예조，간예조급여백려호순10mg/（kg·d）관위，기록대서혈압、심솔，검측흉주동맥여장계막동맥대을선담감적서장특성，검측장계막동맥중총일양화담（NO）급gp91phox 적표체。결과：（1）여년경기고혈압대서상비，중노년고혈압대서적동맥서장공능감약，백려호순치료후서장공능증강。（2）백려호순치료능구증가년경여중노년고혈압대서적장계막동맥총 NO 량，감소 gp91phox 단백표체。결론：고혈압대서동맥내피의뢰적서장공능교정상대서감약차존재년령차이，섭입백려호순가이통과감소gp91phox 표체，증가 NO 량래보호혈관서장공능，해보호작용재년경기여중노년기대서중균존재。
Objective:To investigate the effects of resveratrol on vascular function in age-depentdent spontaneous hypertensive (SH)rats. Methods:Young (8 ~10 weeks)and elderly (9~10 months)SH rats were treated with 10 mg/(kg·d)resveratrol for 2 months.Untreated SH and wistar Kyoto (WK)rats served as controls.Blood pressure and heart rate were monitored.Vascular tension and relaxation characteristic to acetylcholine were detected in thoracic aorta and mesenteric artery.Total nitric oxide (NO)content and gp91phox expression in mesenteric artery was examined. Results:(1 ) Compared with the young SH rats, vasorelaxation function of aged SH rats was abated, and enhancement of diastolic function is was observed after resveratrol treatment.(2)Resveratrol treatment can increase the total amount of NO and decrease the expression of gp91phox protein in mesenteric arteries both in young and elderly SH rats. Conclusion:Artery endothelial dependent diastolic function is weakened in SH rats compared with WY rats and the age differences exist.Chronic resveratrol treatment protects vascular diastolic function by reducing gp91phox expression and elevating NO,and the protection can be observed both in the young and the elderly.